{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:51Z","timestamp":1787775831457,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Endodontic-periodontal lesions present an open wound that might need surgical management using the GTR (guided tissue regeneration) to be managed using a combined approach.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To assess the survival rate and clinical and radiological changes following regenerative periodontal therapy in endodontic-periodontal lesions.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The study assessed 104 cases in 82 subjects with a minimum 2-year follow-up. Following scaling and root planning with\/without endodontic management, regenerative procedures using DBBM with 10% collagen (Group I) or DBBM with collagen membrane (Group II) were done. radiographic bone gain, mobility, relative clinical attachment levels, gingival recession, probing pocket depth, bleeding on probing, and plaque index changes were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In both groups, radiographic bone gains and improved clinical parameters were seen. Greater, but statistically nonsignificant probing depth reduction was seen in the DBBM + 10% collagen group compared to the DBBM + collagen membrane group with 4.54 \u00b1 1.04 mm and 4.06 \u00b1 0.80 mm respectively. Comparable radiographic bone gain was seen in Groups I and II with 5.13 \u00b1 1.52 mm and 5.33 \u00b1 1.82 mm. A 92.33% 5-year survival rate was reported following the regenerative surgery.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Improved radiographic bone and clinical attachment levels are seen following regenerative procedures with DBBM with 10% collagen in endodontic-periodontal lesions. Strict supportive periodontal therapy and oral hygiene can help maintain the successful results of regenerative medicine.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_29_25","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T06:02:45Z","timestamp":1743487365000},"page":"S748-S750","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective Gauging of Survival Rate and Clinical and Radiological Changes Following Regenerative Periodontal Therapy in Endodontic-Periodontal Lesions"],"prefix":"10.4103","volume":"17","author":[{"given":"Sneha","family":"Suresh","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Treena","family":"Kabiraj","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Dental College Azamgarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Abhishek","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Hazaribagh College of Dental Sciences and Hospital, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Hazaribagh College of Dental Sciences and Hospital, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Hari","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Hazaribagh College of Dental Sciences and Hospital, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1902\/jop.1993.64.4.269","article-title":"Periodontal regeneration of human infrabony defects. III. Diagnostic strategies to detect bone gain","volume":"64","author":"Tonetti","year":"1993","journal-title":"J Periodontol"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/prd.12048","article-title":"Clinical concepts for regenerative therapy in intrabony defects","volume":"68","author":"Cortellini","year":"2015","journal-title":"Periodontol 2000"},{"key":"R3-20250513","first-page":"127","article-title":"Clinical and histologic evaluation of anorganic bovine bone collagen with or without a collagen barrier","volume":"24","author":"Hartman","year":"2004","journal-title":"Int J Periodontics Restorative Dent"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/prd.12086","article-title":"Biomaterials for promoting periodontal regeneration in human intrabony defects: A systematic review","volume":"68","author":"Sculean","year":"2015","journal-title":"Periodontol 2000"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/jcpe.12265","article-title":"Treatment of periodontal-endodontic lesions\u2013A systematic review","volume":"41","author":"Schmidt","year":"2014","journal-title":"J Clin Periodontol"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1902\/jop.2010.100144","article-title":"Clinical outcomes after treatment of non-contained intrabony defects with enamel matrix derivative or guided tissue regeneration: A 12-month randomized controlled clinical trial","volume":"82","author":"Siciliano","year":"2011","journal-title":"J Periodontol"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1600-051X.2011.01768.x","article-title":"Periodontal regeneration versus extraction and prosthetic replacement of teeth severely compromised by attachment loss to the apex: 5-year results of an ongoing randomized clinical trial","volume":"38","author":"Cortellini","year":"2011","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_29_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:34Z","timestamp":1787773414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_29_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":7,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_29_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"2025-01-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}