{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:35Z","timestamp":1787840495598,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Purpose:<\/jats:title>\n Our study aimed to evaluate the outcome of decompression and enucleation at a later date as a treatment option for large Odontogenic keratocyst (OKC).<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods:<\/jats:title>\n The study was a prospective study. 50 patients who satisfied the inclusion criteria were considered for the study, seven male and five female. Patients were between the ages range of 21 to 52 years with biopsy-proven OKC. All the patients had cysts in the mandibular region. 36 cysts (72%) were multilocular and 14 (28%) were unilocular. Decompression was done initially, the cyst dimensions were assessed at regular intervals, and enucleation was done once the cyst dimensions were considered satisfactory.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The initial cyst area ranged from 44 cm\n 2<\/jats:sup>\n to 115.3 cm\n 2<\/jats:sup>\n (mean-92.26 cm\n 2<\/jats:sup>\n ). The final cyst area calculated just before definitive surgery ranged from 4.5 cm\n 2<\/jats:sup>\n to 19.5 cm\n 2<\/jats:sup>\n (mean 9.4 cm\n 2<\/jats:sup>\n ). The reduction rate of the cyst between the first and final surgeries ranged from 75% to 91% (mean 89.54%). The Reduction rate of the cystic area was calculated per month and ranged from 3.7% to 12.5%. After the final surgery, a histopathologic examination of the excised specimen revealed that the pathologic tissue in 21 (42%) OKC turned into hypertrophic Squamous Epithelium with no evidence of cystic epithelium or satellite cysts.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We hereby conclude that pre-surgical decompression is a versatile treatment option for OKCs. Provided, the patient is cooperative, it can be used as a primary treatment option for large OKCs, thereby minimizing the extent of surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_303_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:02:53Z","timestamp":1750208573000},"page":"S1957-S1959","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Large Multilocular and Unilocular Odontogenic Keratocysts of Mandible with Decompression as Primary Treatment Modality"],"prefix":"10.4103","volume":"17","author":[{"given":"Madathanapalli","family":"Satish","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Gitam Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Poornima","family":"Sowjanya","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Gitam Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Malleswara","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Anil Neerukonda Institute of Dental sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmabhotla D. J. R. M. V.","family":"Vardhan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Anil Neerukonda Institute of Dental sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Sri","family":"Sathya","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Anil Neerukonda Institute of Dental sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","first-page":"271","article-title":"Uber kiefercysten","volume":"10","author":"Partsch","year":"1892","journal-title":"Dtsch Mschr Zahnheilkd"},{"key":"R2-20250618","first-page":"252","article-title":"Zur behandlung der kieferzysten","volume":"28","author":"Partsch","year":"1910","journal-title":"Dtsch Mschr Zahnheilkd"},{"key":"R4-20250618","first-page":"41","article-title":"Novel method of treating large cysts of jaws in children","volume":"41","author":"Cranin","year":"1994","journal-title":"N Y State Dent J"},{"key":"R5-20250618","first-page":"669","article-title":"Decompression and secondary enucleation of a mandibular cyst. Report of a case","volume":"30","author":"Tucker","year":"1972","journal-title":"J Oral Surg"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tripleo.2007.01.033","article-title":"Surgical management of ameloblastoma in children","volume":"104","author":"Huang","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20250618","first-page":"31","article-title":"The incredible odontogenic keratocyst","volume":"58","author":"Thomas","year":"1992","journal-title":"N Y State Dent J"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_303_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:23:58Z","timestamp":1787837038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_303_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":6,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_303_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}