{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:08Z","timestamp":1787841368769,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to find out the association of adiponectin and resistin levels in gingival crevicular fluid (GCF) with the clinical parameters before and after scaling and root planing in periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 50 patients were recruited from the Outpatient Department of Periodontics, JKK Nattraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India. The protocol was reviewed and approved by the institutional ethical board. Informed consent was obtained from the patients and the study-related procedures were explained. Patients were divided into two groups. Group I (25 patients) consisted of healthy patients. Group II (25 patients) consisted of periodontitis patients. The periodontitis patients after treatment were considered as Group III. GCF samples were collected before treatment and 21 days after treatment. The levels of adiponectin and resistin were evaluated using Immunotag\u2122 Human RETN enzyme-linked immunosorbent assay (ELISA) kit (ITEH0269) and Immunotag\u2122 Human ADP (adiponectin) ELISA kit (ITEH2593). The levels were correlated with the clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were an increase in the mean adiponectin level and a decrease in the mean resistin level at the end of periodontal therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adiponectin which is an anti-inflammatory component was found to increase after periodontal therapy, and resistin which is an inflammatory component has been decreased after periodontal therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_318_21","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:05:28Z","timestamp":1675836328000},"page":"S1178-S1183","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Adiponectin and Resistin Levels in Gingival Crevicular Fluid in Patients with Chronic Periodontitis Before and After Treatment: A Clinico-Biochemical Study"],"prefix":"10.4103","volume":"13","author":[{"given":"P.","family":"Fairlin","sequence":"first","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A. Jacob","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson Raja","family":"James","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamil Selvan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Divya","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/erm.2013.8","article-title":"Inflammatory mediators in the pathogenesis of periodontitis","volume":"15","author":"Yucel-Lindberg","year":"2013","journal-title":"Expert Rev Mol Med"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cytogfr.2007.04.007","article-title":"The emerging role of adipokines as mediators of inflammation and immune responses","volume":"18","author":"Lago","year":"2007","journal-title":"Cytokine Growth Factor 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Res"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"119","DOI":"10.12816\/0024074","article-title":"An evaluation of serum and salivary adipokines (leptin and resistin) levels in periodontal health and disease","volume":"27","author":"Karam","year":"2015","journal-title":"J Baghdad Coll Dent"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/jisp.jisp_108_18","article-title":"Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis","volume":"22","author":"Suresh","year":"2018","journal-title":"J Indian Soc Periodontol"},{"key":"R13-20250920","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/0976-237X.114878","article-title":"Resistin in serum and gingival crevicular fluid as a marker of periodontal inflammation and its correlation with single-nucleotide polymorphism in human resistin gene at -420","volume":"4","author":"Patel","year":"2013","journal-title":"Contemp Clin Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_318_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:51:54Z","timestamp":1787838714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_318_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":12,"journal-issue":{"issue":"Suppl 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