{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:40Z","timestamp":1787772640513,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"\n Background:<\/jats:title>\n Several phyto-chemicals have been identified and suggested as potential therapeutic options for hepatotoxicity management<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n \n To assess the hepatoprotective effect of scopoletin, a pure phyto-chemical, in carbon tetrachloride (CCl\n 4<\/jats:sub>\n )-induced hepatotoxicity model in Wistar rats\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Thirty-six rats in total, six in each group, were utilized in this study. Animals in group 1 received normal saline; those in group 2 received carbon tetrachloride in olive oil (0.5 ml\/kg, i.p. in ratio 1:1); those in groups 3, 4, and 5 received oral scopoletin (1 mg\/kg, 5 mg\/kg, 10 mg\/kg dose-wise groups); and those in group 6 received N-acetyl cysteine (NAC) 150 mg\/kg. Blood sampling was performed on day -3, day 1, and day 7 of the CCl\n 4<\/jats:sub>\n administration. Rats were sacrificed on day 7 of the experiment for histological examination and oxidative stress measurement of the liver\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The 5 mg\/kg scopoletin group showed a maximum reduction in AST levels [727.33 \u00b1 29.15 in medium dose (MD) group vs 1526.66 \u00b1 60.72 in the experimental control (EC) group (\n P<\/jats:italic>\n < 0.001) and ALT levels of 532.66 \u00b1 24.23 in MD group vs 894.83 \u00b1 52.47 in EC (\n P<\/jats:italic>\n < 0.01)]. The dose-dependent action was not observed with scopoletin doses. The protective effect of scopoletin was confirmed by MDA and GSH levels (\n P<\/jats:italic>\n < 0.05) coupled with histo-pathological findings. In the present study, a reversible model of CCl\n 4<\/jats:sub>\n -induced hepatotoxicity was observed to get normalized in a week\u2019s time\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The study confirms the hepatoprotective action of scopoletin in an acute model of hepatic injury with the putative anti-oxidant mechanism.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_333_22","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:31:26Z","timestamp":1676439086000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacological Evaluation of Scopoletin in the Carbon Tetrachloride- Induced Hepatotoxicity Model in Wistar 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