{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:46Z","timestamp":1787758306711,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early childhood caries (ECC) remains a prevalent global health issue, particularly in developing nations. Effective interventions are critical to halting its progression and preventing long-term dental complications. This study aimed to evaluate the effectiveness of different caries-arresting agents in ceasing ECC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A randomized clinical trial was conducted on 150 children aged 2\u20135 years with ECC. Participants were divided into three groups and treated with silver diamine fluoride (SDF), fluoride varnish (FV), or glass ionomer cement (GIC). Caries progression was evaluated at baseline, 3 months, and 6 months using standardized indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SDF showed the highest efficacy in arresting caries lesions, with 85% of lesions arrested by 6 months. FV and GIC exhibited 70% and 60% effectiveness, respectively. Both SDF and FV demonstrated significant reductions in caries progression compared with GIC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:bold>&lt;<\/jats:bold>\n                      0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SDF is the most effective agent in ceasing ECC progression, followed by FV and GIC. Routine use of SDF could significantly impact pediatric dental health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_337_25","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:00:18Z","timestamp":1760212818000},"page":"S3515-S3517","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Different Agents in Ceasing Early Childhood Caries: A Clinical Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Debkant","family":"Jena","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, St Christopher Hospital for Children, Philadelphia, Pennsylvania, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purushottam","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of New England, Maine, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Sheetal","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Dentistry Program, Ibn Sina National Medical College, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha C","family":"Jugade","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akriti","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Private Consultant, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"R1-20260217","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: A global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"R2-20260217","first-page":"466","article-title":"Silver diamine fluoride treatment considerations in children's caries management","volume":"38","author":"Crystal","year":"2016","journal-title":"Pediatr Dent"},{"key":"R3-20260217","first-page":"135","article-title":"Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs","volume":"39","author":"Crystal","year":"2017","journal-title":"Pediatr Dent"},{"key":"R4-20260217","doi-asserted-by":"crossref","first-page":"e0238590","DOI":"10.1371\/journal.pone.0238590","article-title":"Effect of silver diamine fluoride and proanthocyanidin on resistance of carious dentin to acid challenges","volume":"15","author":"Firouzmandi","year":"2020","journal-title":"PLoS One"},{"key":"R5-20260217","first-page":"201","article-title":"Clinical trials of silver diamine fluoride in arresting caries among children: A systematic review","volume":"1","author":"Gao","year":"2016","journal-title":"JDR Clin Trans Res"},{"key":"R6-20260217","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/154407370802000102","article-title":"Evidence-based effectiveness of topical fluorides","volume":"20","author":"Marinho","year":"2008","journal-title":"Adv Dent Res"},{"key":"R7-20260217","first-page":"CD001830","article-title":"Sealants for preventing dental decay in the permanent teeth","author":"Ahovuo-Saloranta","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"R8-20260217","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13063-020-4088-7","article-title":"Preventing early childhood caries with silver diamine fluoride: Study protocol for a randomised clinical trial","volume":"21","author":"Gao","year":"2020","journal-title":"Trials"},{"key":"R9-20260217","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/idj.12320","article-title":"Mechanisms of silver diamine fluoride on arresting caries: A literature review","volume":"68","author":"Zhao","year":"2018","journal-title":"Int Dent J"},{"key":"R10-20260217","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.18203\/2320-6012.ijrms20213094","article-title":"A randomized split mouth clinical trial of the application of the desensitizer agents for tooth sensitivity","volume":"9","author":"Reddy","year":"2021","journal-title":"Int J Res Med Sci"},{"key":"R11-20260217","first-page":"672","article-title":"Evaluation of fluoride uptake of two fluoride varnishes into and onto the enamel surface at different temperatures: An in vitro Study","volume":"15","author":"Vishwakarma","year":"2022","journal-title":"Int J Clin Pediatr Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_337_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:13:11Z","timestamp":1787757191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_337_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":11,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_337_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,10]]},"assertion":[{"value":"2025-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}