{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:09Z","timestamp":1787071629291,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children with down syndrome (DS) often experience a higher prevalence and severity of periodontal disease compared to typically developing children. This can negatively impact their oral health-related quality of life (OHRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to assess the periodontal status and OHRQoL in children with DS and investigate the association between these factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted involving 50 children with DS and 50 age-matched typically developing children. Periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket depths (PPD), and clinical attachment loss (CAL), were recorded. OHRQoL was evaluated using the Child-OIDP questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Children with DS exhibited significantly higher PI scores (mean difference = 0.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), GI scores (mean difference = 0.62,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), PPD (mean difference = 1.2 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and CAL (mean difference = 0.9 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) compared to the control group. OHRQoL scores were significantly lower in the DS group (mean difference = \u20137.5,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Regression analysis showed a significant negative correlation between PPD and OHRQoL scores (\u03b2 = \u20130.62,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), indicating that greater periodontal disease severity was associated with poorer OHRQoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study confirms that children with DS experience compromised periodontal health and reduced OHRQoL. These findings emphasize the need for early and comprehensive oral healthcare interventions to improve both periodontal health and overall well-being in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_365_25","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T14:00:43Z","timestamp":1757944843000},"page":"S2196-S2198","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal Status and Oral Health-Related Quality of Life in Children with Down Syndrome"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuj Singh","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Periodontology, People\u2019s Dental Academy, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Baheti","sequence":"additional","affiliation":[{"name":"Department of Esthetics and Restorative Dentistry, Perfect Smiles Clinic, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Sugandhi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre, Nave Pargaon, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Vananchal Dental College and Hospital, Garhwa, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreejith","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maharishi Markandeshwar College of Dental Sciences and Research MM (DU), Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr. R. 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Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"R1-20250930","first-page":"954","article-title":"Oral health-related quality of life (OHRQoL) of children with down syndrome and their families:A cross-sectional study","volume":"8","author":"AlJameel","year":"2021","journal-title":"Children (Basel)"},{"key":"R2-20250930","first-page":"e73852","article-title":"Salivary markers of oxidative stress and their relation to periodontal and dental status among children with down syndrome","volume":"16","author":"Hamonari","year":"2024","journal-title":"Cureus"},{"key":"R3-20250930","doi-asserted-by":"crossref","first-page":"87","DOI":"10.17245\/jdapm.2021.21.2.87","article-title":"Dental treatment under general anesthesia for patients with severe disabilities","volume":"21","author":"Choi","year":"2021","journal-title":"J Dent Anesth Pain Med"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"148","DOI":"10.12968\/denu.2001.28.3.148","article-title":"Down's syndrome and oral care","volume":"28","author":"Fiske","year":"2001","journal-title":"Dent Update"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/jispcd.JISPCD_396_18","article-title":"Oral health status among children with down syndrome in Dubai, United Arab Emirates","volume":"9","author":"Ghaith","year":"2019","journal-title":"J Int Soc Prev Community Dent"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/S0140-6736(00)03259-1","article-title":"Pain expression and stimulus localisation in individuals with Down's syndrome","volume":"356","author":"Hennequin","year":"2000","journal-title":"Lancet"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/00016357.2020.1824015","article-title":"Parents'perceptions of oral health, general health and dental health care for children with down syndrome in Sweden","volume":"79","author":"Stensson","year":"2021","journal-title":"Acta Odontol Scand"},{"key":"R8-20250930","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s41687-020-00211-y","article-title":"Down syndrome and oral health:Mothers'perception on their children's oral health and its impact","volume":"4","author":"AlJameel","year":"2020","journal-title":"J Patient Rep Outcomes"},{"key":"R9-20250930","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0022034517693566","article-title":"Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015:A systematic analysis for the global burden of diseases, injuries, and risk factors","volume":"96","author":"Kassebaum","year":"2017","journal-title":"J Dent Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_365_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:49:52Z","timestamp":1787068192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_365_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":9,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_365_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-02-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}