{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:59Z","timestamp":1787840459030,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic periodontitis is a prevalent inflammatory disease that necessitates effective treatment strategies. This study aimed to compare the efficacy of curcumin-loaded nanofibers with metronidazole gel in treating chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A double-blind, randomized controlled trial was conducted involving patients diagnosed with chronic periodontitis. Participants were randomly assigned to receive either curcumin-loaded nanofibers or metronidazole gel as an adjunct to scaling and root planning. Clinical parameters were assessed at baseline, one month, and three months post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both treatment groups exhibited significant improvements in probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) at all follow-up intervals compared to baseline. Notably, the curcumin-loaded nanofiber group demonstrated statistically significant greater reductions in PD and CAL at three months compared to the metronidazole gel group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Curcumin-loaded metronidazole was used in nanofibers technology on chronic periodontitis patients, showing the possibility of improving therapeutic results, especially in posteriori periods, compared to the conventional metronidazole gel.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_373_25","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:00:26Z","timestamp":1755777626000},"page":"S2721-S2723","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin-loaded Nanofibers versus Metronidazole Gel in the Treatment of Chronic Periodontitis: A Double-blind, Randomized Controlled Trial"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuj Singh","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Periodontology, People\u2019s Dental Academy, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Gokul","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Buraydah College of Dentistry and Pharmacy, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Autonomous State Medical College, Akbarpur, Kanpur Dehat, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Hanumantha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Research Institute, Ballari Medical College and Research Centre (BMCRC), Ballari, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr RR Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshna","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, College of Dental Science and Hospital, Rau, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s10096-011-1484-7","article-title":"In vivo evaluation of a metronidazole-containing gel for the adjuvant treatment of chronic periodontitis: Preliminary results","volume":"31","author":"Miani","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1034\/j.1600-051x.2000.027012910.x","article-title":"Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel","volume":"27","author":"Griffiths","year":"2000","journal-title":"J Clin 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study","volume":"16","author":"Chakraborty","year":"2024","journal-title":"Cureus"},{"key":"R9-20250930","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1007\/s00784-020-03631-8","article-title":"Local delivery therapies as adjuvants to non-surgical periodontal treatment of periodontitis grade C: A systematic review","volume":"24","author":"Gomes","year":"2020","journal-title":"Clin Oral Investig"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_373_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:23:15Z","timestamp":1787836995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_373_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":9,"journal-issue":{"issue":"Suppl 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