{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:57Z","timestamp":1787772177765,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Aim and Objectives:<\/jats:title>\n To compare and evaluate the clinical efficacy of \u201cofloxacin incorporated L-PRF\u201d and \u201cL-PRF alone\u201d when used as an adjuvant to non-surgical periodontal therapy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A split-mouth study was conducted in 50 patients diagnosed as chronic periodontitis with pocket depth \u22656 with at least one site in each quadrant. All patients underwent scaling and root planning. Test site received with ofloxacin incorporated L-PRF and control site received L-PRF alone. Clinical parameters pocket depth (PD), plaque index (PI), and gingival bleeding index (GBI) were recorded at baseline and 1 month after scaling and root planning.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In total, 100 sites were treated (50 test group and 50 control group) with no uneventful healing effects. Statistically significant decreases in PD (\n P<\/jats:italic>\n = .0001 for both test and control groups), PI (\n P<\/jats:italic>\n = .001), GBI (\n P<\/jats:italic>\n = .001 for both groups), between pre-treatment and 1 month post-treatment were noted in both test and control groups. For intergroup comparisons, there was a statistically significant difference in all clinical indices (\n P<\/jats:italic>\n > .005).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Use of L-PRF with ofloxacin as an adjuvant to non-surgical periodontal therapy showed better improvements in clinical parameters.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_382_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:31:26Z","timestamp":1713270686000},"page":"S1369-S1372","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of L-PRF and Ofloxacin Incorporated L-PRF as an Adjunctive to SRP-A Split-Mouth Randomized Clinical Trial"],"prefix":"10.4103","volume":"16","author":[{"given":"Balaji V.","family":"Rengaswami","sequence":"first","affiliation":[{"name":"Department of Periodontics and Implant Dentistry, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Sudhakar","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implant Dentistry, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikandan","family":"Dhanasekaran","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implant Dentistry, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokulnivas","family":"Muthuvijayan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Implant Dentistry, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/jcpe.13063","article-title":"Incorporating antibiotics into platelet-rich fibrin: A novel antibiotics slow-release biological device","volume":"46","author":"Polak","year":"2019","journal-title":"J Clin Periodontol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1902\/jop.1989.60.1.67","article-title":"Scaling and root planing effectiveness: The effect of root surface access and operator experience","volume":"60","author":"Brayer","year":"1989","journal-title":"J Periodontol"},{"issue":"Suppl 3","key":"R3-20240829","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J Clin Periodontol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1902\/annals.2003.8.1.115","article-title":"Systemic anti-infective periodontal therapy. 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Part III: Leucocyte activation: A new feature for platelet concentrates?","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/JPER.19-0216","article-title":"Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro","volume":"91","author":"Nasirzade","year":"2020","journal-title":"J Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_382_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:31:50Z","timestamp":1787769110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_382_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":12,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_382_23","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-06-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}