{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:01Z","timestamp":1787841541511,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Objectives:<\/jats:title>\n The purpose of this study was to assess, in a tertiary care context, the significance of C-reactive protein (CRP) in salivary gland illness.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective research included 100 consecutive individuals with symptoms indicative of illness of the salivary glands. Demographic information, clinical information, and presenting symptoms were noted. Studies on salivary gland imaging were conducted, and a high-sensitivity test was used to quantify CRP levels. Radiology and clinical data were used to classify the disease\u2019s severity. The relationship between CRP levels and illness severity was examined using statistical methods such as regression analysis and correlation testing.<\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n \n There was a strong correlation between the severity of salivary gland illness and elevated CRP levels. There was a statistically significant correlation (\n P<\/jats:italic>\n < 0.05) between high CRP levels and the severity of salivary gland disease. When compared to patients with mild or moderate illness, patients with severe disease had greater CRP levels. In all severity groups, pain was the most common presenting symptom, followed by swelling and trouble swallowing. The variable character of disorders affecting the salivary glands was highlighted by the considerable variation in symptom distribution according to disease severity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In conclusion, current research points to CRP as a possible biomarker for determining the degree of illness in conditions affecting the salivary glands. Elevated CRP levels have been linked to severe illness, which suggests that CRP may be useful in risk assessment and therapy selection. To confirm these results and investigate the therapeutic applications of CRP-guided treatment in salivary gland disorders, more investigation is necessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_383_24","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:43:34Z","timestamp":1722566614000},"page":"S2764-S2766","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Role of C-Reactive Protein in Salivary Gland Disease: A Clinical Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Batchu Pavan","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Gowtam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Manoj","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Chawla","sequence":"additional","affiliation":[{"name":"Associate Professor, School of Dentistry, Central Asian University, Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mujoo","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Oral Medicine and Radiology, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neshaneni Satish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, G. Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti G","family":"Makwana","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Crown and Bridges, College of Dental Sciences and Hospital, Amarghdh, Bhavnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"R1-20240829","first-page":"101","article-title":"C-reactive protein and its inflammatory role in various diseases","volume":"5","author":"Chen","year":"2014","journal-title":"Aging Dis"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: Normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J Prosthet Dent"},{"key":"R3-20240829","first-page":"1533","article-title":"Cutaneous manifestations of Sj\u00f6gren syndrome: A comprehensive review","volume":"9","author":"Lee","year":"2020","journal-title":"J Clin Med"},{"issue":"Suppl","key":"R4-20240829","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.14219\/jada.archive.2008.0353","article-title":"Measuring salivary flow: Challenges and opportunities","volume":"139","author":"Navazesh","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12116","article-title":"The physiology of salivary secretion","volume":"70","author":"Proctor","year":"2016","journal-title":"Periodontol 2000"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/ard.2004.025676","article-title":"Primary Sj\u00f6gren's syndrome: New clinical and therapeutic concepts","volume":"64","author":"Ramos-Casals","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/clinchem\/39.4.635","article-title":"Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: A new serum marker of bone collagen degradation","volume":"39","author":"Risteli","year":"1993","journal-title":"Clin Chem"},{"issue":"2 Suppl 96","key":"R8-20240829","first-page":"S9","article-title":"Prevalence and clinical impact of fibromyalgia in patients with primary Sj\u00f6gren's syndrome","volume":"34","author":"Choi","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1023\/A:1008879920140","article-title":"Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan)","volume":"9","author":"Kono","year":"1998","journal-title":"Cancer Causes Control"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_383_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:00:41Z","timestamp":1787839241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_383_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":9,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_383_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}