{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:48Z","timestamp":1787070768324,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Objectives:<\/jats:title>\n The purpose of this study is to look at how often premalignant oral diseases are among patients who visit a tertiary care center, as well as how often these problems progress to become mouth malignancies.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Between 2017 and 2022, 200 patients at a tertiary care facility who were identified with premalignant oral lesions had their medical records retrospectively examined. Information on lesion features, histological results, and demographics was gathered. Statistical analysis was used to determine the prevalence of premalignant oral lesions and the rate at which these lesions turned into oral malignancies, with a significance threshold of\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n \n The research population\u2019s mean age was 55 years (SD \u00b1 10), with a 65% male preponderance. The most prevalent premalignant lesions were leukoplakia (45%), erythroplakia (30%), and oral submucous fibrosis (25%). Remarkably, during follow-up, 40% of patients showed development of premalignant lesions into mouth malignancies. Based on statistical analysis, there were significant correlations (\n P<\/jats:italic>\n < 0.05) between dysplastic alterations, age, tobacco use, and the development of oral malignancies from premalignant lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In conclusion, this study highlights the need of early diagnosis and focused therapies in tertiary care settings by offering important insights into the occurrence and evolution of premalignant oral lesions. The results provide important information that may be used to create screening programs and preventive measures that will lessen the incidence of oral cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_384_24","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:03:16Z","timestamp":1718258596000},"page":"S2563-S2565","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Premalignant Conditions and Their Transformation Into Oral Cancers: A Clinical Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Batchu Pavan","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Narra","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuyyuru Vidya","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu Gowtham","family":"Marella","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kamineni Institute of Dental Sciences, Sreepuram, Narketpally, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saudamini G.","family":"More","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mujoo","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Radiology, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neshaneni Satish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, G. Pulla Reddy Dental College and Hospital, Kurnool, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3322\/canjclin.52.4.195","article-title":"Oral cancer and precancerous lesions","volume":"52","author":"Neville","year":"2002","journal-title":"CA Cancer J Clin"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1600-0528.1980.tb01302.x","article-title":"Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers","volume":"8","author":"Gupta","year":"1980","journal-title":"Community Dent Oral Epidemiol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.oraloncology.2007.06.011","article-title":"Critical evaluation of diagnostic aids for the detection of oral cancer","volume":"44","author":"Lingen","year":"2008","journal-title":"Oral Oncol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1056\/NEJMoa065497","article-title":"Case-control study of human papillomavirus and oropharyngeal cancer","volume":"356","author":"D'Souza","year":"2007","journal-title":"N Engl J Med"},{"key":"R6-20240829","first-page":"11884","article-title":"Essentials of oral cancer","volume":"8","author":"Rivera","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.oooo.2017.12.011","article-title":"Oral potentially malignant disorders: Risk of progression to malignancy","volume":"125","author":"Speight","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/odi.12095","article-title":"Malignant transformation of oral leukoplakia in a well-defined cohort of 144 patients","volume":"20","author":"Brouns","year":"2014","journal-title":"Oral Dis"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_384_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:16Z","timestamp":1787067376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_384_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,7]]},"references-count":8,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_384_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,7]]},"assertion":[{"value":"2024-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}