{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:12Z","timestamp":1787841552420,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Targeted and efficient therapy strategies are necessary to address the global threat that chronic periodontitis poses to oral health. Antibiotic resistance is one drawback of traditional methods like scaling and root planing in conjunction with systemic antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Techniques:<\/jats:title>\n                    <jats:p>A study with 120 people who had been diagnosed with chronic periodontitis was done using randomized controlled trials. The subjects were grouped as the Feracrylum group and the placebo group. Clinical measures were measured at baseline and again after 12 weeks. These parameters included gingival index, clinical attachment level, and \u201cprobing pocket depth (PD).\u201d A 3% solution was locally applied to periodontal pockets in the Feracrylum group, whereas a saline solution was given to the placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>\n                      As compared with other cohorts, the Feracrylum group showed a substantial improvement in clinical attachment level and a significant decrease in PD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Although not statistically significant, the gingival index reduction in the Feracrylum group showed a tendency in the direction of better gingival health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In summary, feracrylum has the potential as a localized medication delivery adjunct for chronic periodontitis, leading to positive clinical results. Larger sample numbers and longer follow-up times are required for future studies to confirm these results and maximize the use of feracrylum in periodontal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_388_24","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:21:15Z","timestamp":1722565275000},"page":"S2655-S2657","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Feracrylum\u2014An Unexplored Aspect of Local Drug Delivery in Treating Chronic Periodontitis: An Original Research"],"prefix":"10.4103","volume":"16","author":[{"given":"Karthika","family":"Janardhan","sequence":"first","affiliation":[{"name":"Department of Periodontics, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiral","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5005\/jp-journals-10024-2828","article-title":"A comparative evaluation of subgingivally delivered 2% curcumin and 0.2% chlorhexidine gel adjunctive to scaling and root planing in chronic periodontitis","volume":"21","author":"Siddharth","year":"2020","journal-title":"J Contemp Dent Pract"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/jisp.jisp_207_19","article-title":"Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis:A pilot randomized controlled clinical trial","volume":"24","author":"Guru","year":"2020","journal-title":"J Indian Soc Periodontol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12903-020-1021-0","article-title":"Adjunctive subgingival application of chlorhexidine gel in nonsurgical periodontal treatment for chronic periodontitis:A systematic review and meta-analysis","volume":"20","author":"Zhao","year":"2020","journal-title":"BMC Oral Health"},{"key":"R4-20240829","first-page":"625","article-title":"Ozone gel in chronic periodontal disease:A randomized clinical trial on the anti-inflammatory effects of ozone application","volume":"10","author":"Colombo","year":"2021","journal-title":"Biology (Basel)"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s12663-018-1156-6","article-title":"Efficacy of feracrylum as topical hemostatic agent in therapeutically anticoagulated patients undergoing dental extraction:A comparative study","volume":"18","author":"Rai","year":"2019","journal-title":"J Maxillofac Oral Surg"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12903-020-01247-8","article-title":"Effect of chlorhexidine chip as an adjunct in non-surgical management of periodontal pockets:A meta-analysis","volume":"20","author":"Ma","year":"2020","journal-title":"BMC Oral Health"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1002\/ptr.7208","article-title":"Clinical efficacy of curcumin versus chlorhexidine as an adjunct to scaling and root planing for the treatment of periodontitis:A systematic review and meta-analysis","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother Res"},{"key":"R8-20240829","first-page":"151","article-title":"Clinical, radiographic and histological observations of the radicular pulp following \u201cferacrylum\u201dpulpotomy","volume":"21","author":"Prabhu","year":"1997","journal-title":"J Clin Pediatr Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_388_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:01:19Z","timestamp":1787839279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_388_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":8,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_388_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}