{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:16Z","timestamp":1787841556036,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Genetic polymorphisms are common and contribute significantly to human illnesses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study was carried out to evaluate the importance of genetic variations in the genes expressing cancer-metabolizing enzymes (CYP1A1 and GSTM1) in individuals experiencing oral submucous fibrosis (OSMF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>Based on the clinical and histological characteristics of OSMF, 40 patients were chosen for the study; 10 of these patients had considerable polymorphism and malignant transformation; therefore, they were placed in a different group. After receiving written agreement, 30 normal subject patients were also picked for the study. For both normal and OSMF patients, tissue samples and 2 ml of peripheral venous blood were drawn from the arm vein and placed in a heparinized test tube. Electrophoresis on 0.8% agarose gel was used to verify genomic DNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The GSTM1 polymorphism, CYP1A1 polymorphism was 10.41% and 15.27% in normal subjects. The GSTM1 polymorphsm, CYP1A1 polymorphism was 16.21% and 8.14% in early OSMF. The GSTM1 polymorphsm, CYP1A1 polymorphism was 20.31% and 28.56% in moderate OSMF. The GSTM1 polymorphsm, CYP1A1 polymorphism was 8.12% and 12.54% in moderate OSMF. Finally, GSTM1 polymorphism was 60.47% in OSMF+ CA, while CYP1A1 polymorphism was 40.21%. The GSTM1 gene polymorphism and CYP1A1 gene polymorphism were maximum in OSMF+ CA category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a significant role of genetic variations in the genes expressing cancer-metabolizing enzymes (CYP1A1) and GSTM1 in individuals experiencing OSMF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_413_24","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:42:42Z","timestamp":1722566562000},"page":"S2785-S2787","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Importance of Genetic Polymorphisms in Genes Expressing Cancer-Metabolizing Enzymes (Cyp1a1 and Gstm1) in Oral Submucous Fibrosis"],"prefix":"10.4103","volume":"16","author":[{"given":"Devina","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Public Health Dentistry, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarang","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department Oral Medicine and Radiology, Government College of Dentistry, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Rungta Dental College, Bhilai, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash Chandra","family":"Dash","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Hittalamani","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Yogita Dental College and Hospital, Khed, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanpal Singh","family":"Makkad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"R1-20240829","first-page":"1509","article-title":"Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer","volume":"12","author":"Hashibe","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3349\/ymj.2007.48.2.233","volume":"48","author":"Cha","year":"2007","journal-title":"Yonsei Med J"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.7314\/APJCP.2013.14.6.3535","article-title":"Genetic deletions of GSTM1 and GSTT1 in head and neck cancer: Review of the literature from 2000 to 2012","volume":"14","author":"Masood","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"R4-20240829","first-page":"4385","article-title":"Clinical evaluation of effect of aloevera 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