{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:34Z","timestamp":1787071354660,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Limited studies are available to evaluate the nonsurgical treatment with or without diode laser (DL) decontamination in chronic periodontitis patients with type 2 diabetes mellitus (T2DM). The study aimed to compare the outcomes of nonsurgical periodontal therapy with or without adjunct use of diode laser in patients with T2DM and periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 26 patients with periodontitis and T2DM (hemoglobin A1c [HbA1c] \u22656.5%) were selected and divided into test and control groups. Both the groups received nonsurgical periodontal therapy (NSPT) in two sessions one week apart. In test group, scaling and root planing was followed by DL application and in control group, by sham laser application. Clinical parameters, including plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL), coupled with HbA1c were carried out at baseline and at intervals of three and six months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A mean PPD reduction of 36.74% in the test and 33.92% in the control group was seen. In intragroup comparisons, there was a statistically significant result (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) from baseline to six months in PI, GI, PPD and CAL. A statistically significant improvement of HbA1c value was observed from baseline to six months in the LASER group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LASER-assisted photo-biomodulation in combination with NSPT showed better results in patients with periodontitis and T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_432_25","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:01:56Z","timestamp":1763661716000},"page":"S3728-S3731","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diode Laser Application as an Adjunct to Nonsurgical Periodontal Therapy in Patients with Periodontitis and Type 2 Diabetes Mellitus\u2014A Comparative Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Rupasree","family":"Gundala","sequence":"first","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Shree","family":"Ramalakshmi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehjubah","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounica","family":"Batchu","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga Jyothi","family":"Chadalavada","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra Dev","family":"Jampani","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"R1-20260217","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10103-016-2086-5","article-title":"Role of lasers as an adjunct to scaling and root planing in patients with type 2 diabetes mellitus: A systematic review","volume":"32","author":"Abduljabbar","year":"2017","journal-title":"Lasers Med Sci"},{"key":"R2-20260217","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0757.2001.22250103.x","article-title":"Relationship between periodontal disease and systemic health","volume":"25","author":"Garcia","year":"2001","journal-title":"Periodontology 2000"},{"key":"R3-20260217","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1902\/jop.2008.070503","article-title":"Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus","volume":"79","author":"Da Cruz","year":"2008","journal-title":"J Periodontol"},{"key":"R4-20260217","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1834-7819.2011.01652.x","article-title":"Non-surgical periodontal therapy affects metabolic control in diabetics: A randomized controlled clinical trial","volume":"57","author":"Moeintaghavi","year":"2012","journal-title":"Aust Dent J"},{"key":"R5-20260217","first-page":"513","article-title":"Use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. A randomized controlled clinical trial","volume":"31","author":"Caruso","year":"2008","journal-title":"New Microbiol"},{"issue":"Suppl. 8","key":"R6-20260217","first-page":"S94","article-title":"Global epidemiology of dental caries and severe periodontitis \u2013a comprehensive review","volume":"44","author":"Frencken","year":"2017","journal-title":"J Clin Periodontol"},{"key":"R7-20260217","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis an introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol 2000"},{"key":"R8-20260217","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"R9-20260217","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2337\/diacare.18.4.440","article-title":"Kinetics of HbA1c, glycated albumin, and fructosamine and analysis of their weight functions against preceding plasma glucose level","volume":"18","author":"Tahara","year":"1995","journal-title":"Diabetes Care"},{"key":"R10-20260217","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/0006-291X(69)90685-8","article-title":"Studies of an unusual haemoglobin in patients with diabetes mellitus","volume":"36","author":"Rahbar","year":"1969","journal-title":"Biochem Bio Phys Res Commun"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_432_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:49Z","timestamp":1787067889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_432_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":10,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_432_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-02-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}