{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:40Z","timestamp":1787840500923,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n The group of health conditions MetS includes obesity, high blood pressure, poor blood fat control, and insulin resistance, making people more likely to develop heart diseases and type 2 diabetes. Younger research shows that dental bacteria cause more bodywide swelling, hurting MetS patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Study included 100 MetS patients together with 100 healthy individuals having chronic periodontitis symptoms. Research team members measured the level of periodontal tissue structure loss with PPD and CAL measurements. The researchers took subgingival plaque samples from patients to perform the polymerase chain reaction test for\n Porphyromonas gingivalis<\/jats:italic>\n ,\n Aggregatibacter actinomycetemcomitans<\/jats:italic>\n , and\n Tannerella forsythia<\/jats:italic>\n detection. Samples of blood tested for inflammation provided numerical values determining CRP, IL-6, and TNF-\u03b1 levels in the body. We performed independent\n t<\/jats:italic>\n -test and Pearson\u2019s correlation tests for our statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n People with MetS had stronger periodontal inflammation than others because their gum depths measured 4.8 \u00b1 1.2 mm, and gum damage reached 5.2 \u00b1 1.5 mm when compared to the control group (PPD: 3.2 \u00b1 0.9 mm, CAL: 3.5 \u00b1 1.1 mm;\n P<\/jats:italic>\n < 0.05). MetS patients had more\n P. gingivalis<\/jats:italic>\n ,\n A. actinomycetemcomitans<\/jats:italic>\n , and\n T. forsythia<\/jats:italic>\n bacteria in their mouths than the control group at\n P<\/jats:italic>\n < 0.05. MetS patients revealed higher CRP amounts in their blood tests (4.2 \u00b1 1.1 mg\/L) than regular participants (2.1 \u00b1 0.8 mg\/L). Testing showed the connection between bacteria count and inflammation markers was strong.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Research shows that periodontal disease microbes directly relate to higher inflammatory values in people who have metabolic syndrome. The research shows periodontal infections play a role in raising inflammation throughout the body of MetS patients when managing their health condition needs attention.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_436_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:01:12Z","timestamp":1750208472000},"page":"S1808-S1810","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Link Between Periodontal Pathogens and Systemic Inflammatory Markers in Patients with Metabolic Syndrome"],"prefix":"10.4103","volume":"17","author":[{"given":"Ramanarayana","family":"Boyapati","sequence":"first","affiliation":[{"name":"Department of Periodontology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Krishna Prasad","family":"Vudathaneni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Columbus Regional Hospital, Columbus, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruparani","family":"Bodduru","sequence":"additional","affiliation":[{"name":"Department of Periodontology, MNR Dental College and Hospital, Sangareddy, Telanagana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Todima","sequence":"additional","affiliation":[{"name":"General Dentistry, Oak Tree Dental clinic, Ashburn, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankineedu Babu","family":"Dasari","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Meharry Medical College School of Dentistry, Mt Juliet, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Chintala","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Maxillofacial Radiology, Malla Reddy Institute of Dental Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12271","article-title":"Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol 2000"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol 2000"},{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1210\/jc.2012-3552","article-title":"Association between metabolic syndrome and periodontitis: A systematic review and meta-analysis","volume":"98","author":"Nibali","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1111\/jcpe.12089","article-title":"Working group 1 of the joint EFP\/AAP workshop. Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the joint EFP\/AAP workshop on periodontitis and systemic diseases","volume":"40","author":"Tonetti","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R7-20250618","first-page":"1069","article-title":"Periodontitis related to metabolic syndrome, cardiovascular disease, and BMI in an elderly population","volume":"47","author":"Bengtsson","year":"2020","journal-title":"J Clin Periodontol"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1097\/MD.0000000000000292","article-title":"Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease: A meta-analysis","volume":"93","author":"Wang","year":"2014","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_436_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:00Z","timestamp":1787837040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_436_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_436_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-02-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}