{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:19:23Z","timestamp":1787775563792,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"\n Background:<\/jats:title>\n Asthma is a chronic inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness, and remodeling. Asthma prevalence has increased significantly globally over the last decade, and it remains incurable to this date.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objectives:<\/jats:title>\n The present study evaluated some of the antiasthmatic medicinal plants to assess their mode of action.<\/jats:p>\n <\/jats:sec>\n \n Materials and Method:<\/jats:title>\n Animal models for milk-induced leukocytosis, milk-induced eosinophilia, mast cell degranulation, clonidine-induced catalepsy, and active paw anaphylaxis were used to assess the pharmacological effects of Ammi visnaga, Medicago sativa, and Urtica dioica.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mice pretreated with diazepam, methanolic extract of\n M. sativa<\/jats:italic>\n , and\n U. dioica<\/jats:italic>\n exhibited significant (\n P<\/jats:italic>\n < 0.05) inhibition in milk-induced leukocytosis. However, only\n M. sativa<\/jats:italic>\n showed statistically significant (\n P<\/jats:italic>\n < 0.05) results. All plants showed a statistically significant (\n P<\/jats:italic>\n < 0.05) tendency to decrease milk-induced eosinophilia. Methanolic extracts of all plants significantly (\n P<\/jats:italic>\n < 0.05) protected mast cells against degranulation by clonidine.\n A. visnaga<\/jats:italic>\n and\n U. dioica<\/jats:italic>\n significantly (\n P<\/jats:italic>\n < 0.05) protected mice against clonidine-induced catalepsy. An acute treatment by\n M. sativa<\/jats:italic>\n potentiated the catalepsy, while it significantly inhibited the catalepsy (\n P<\/jats:italic>\n < 0.05) upon chronic treatment. In the allergic inflammation model, methanolic extracts of all plants under study decreased paw thickness in a statistically significant manner (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n All the three plants in this study demonstrated anti-inflammatory and antihistaminic effects, as well as decreased paw thickness, validate anti-allergic properties.\n A. visnaga<\/jats:italic>\n showed a mast cell-stabilizing effect.\n A. visnaga<\/jats:italic>\n and\n U. dioica<\/jats:italic>\n inhibited the histamine-mediated clonidine-induced catalepsy from mast cells which proves the antihistaminic activity of these plants.\n <\/jats:p>\n 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