{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:49Z","timestamp":1787840449003,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontitis is an inflammatory disease of the supporting tissue leading to progressive destruction of periodontal ligament and alveolar bone, often resulting in furcation defects. Treatment typically involves periodontal flap surgery with osteoplasty and odontoplasty using materials like hydroxyapatite and demineralized freeze-dried bone allograft (DFDBA). This study compares the efficacy of DFDBA alone and combined with amniotic membrane (AM) in the treatment of grade II furcation defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>30 patients with grade II furcation defects in mandibular first molars were randomly divided into two groups: Group A (control) received DFDBA, and Group B (experimental) received DFDBA with AM. Clinical and radiographic parameters, including plaque index (PI), gingival index (GI), vertical probing depths (VPD), clinical attachment level (CAL) and radiographic bone gain, were assessed at baseline, 1, 3, and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>DFDBA, with or without AM, significantly regenerates grade II furcation defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_455_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:02:10Z","timestamp":1750208530000},"page":"S1814-S1816","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Role of Demineralized Freeze-Dried Bone Allograft and Amniotic Membrane in Periodontal Osseous Defects: A Clinical and Radiographic Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Deepti","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Periodontology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Arif","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Gowrav","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Babu Banarasi Das College of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Purvanchal Institute of Dental Sciences, GIDA, Gorakhpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Babu Banarasi Das College of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R3-20250618","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"R4-20250618","first-page":"106","article-title":"Amniotic membrane: A novel material for regeneration and repair","volume":"18","author":"Chopra","year":"2013","journal-title":"J Biomim Biomater Tissue Eng"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/jop.2016.160260","article-title":"Demineralized freeze-dried bone allograft with amniotic membrane in the treatment of periodontal intrabony defects-12 month randomized controlled clinical trial","volume":"1","author":"Sali","year":"2016","journal-title":"J Periodontol"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"255","DOI":"10.11607\/prd.2901","article-title":"Volumetric assessment of regenerative efficacy of demineralized freeze-dried bone allograft with or without amnion membrane in grade II furcation defects: A cone beam computed tomography study","volume":"37","author":"Pajnigara","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/joca.1999.0309","article-title":"Neochondrogenesis in repair of full-thickness articular cartilage defects using free autogenous periosteal grafts in the rabbit. A follow-up in six months","volume":"8","author":"Carranza-Bencano","year":"2000","journal-title":"Osteoarthritis Cartilage"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1902\/jop.1996.67.2.150","article-title":"Fate of demineralized freeze-dried bone allograft in human intrabony defects","volume":"67","author":"Mark","year":"1996","journal-title":"J Periodontol"},{"key":"R9-20250618","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2174\/1874210601408010056","article-title":"Mechanisms of guided bone regeneration: A review","volume":"8","author":"Liu","year":"2014","journal-title":"Open Dent J"},{"key":"R10-20250618","first-page":"124","article-title":"A Novel dehydrated amnion allograft for use in the treatment of gingival recession: An observational case series","volume":"1","author":"Brian","year":"2009","journal-title":"J Imp Adv Clin Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_455_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:58Z","timestamp":1787836978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_455_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":8,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_455_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-02-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}