{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:31:28Z","timestamp":1786728688870,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Facial development involves an intricate regulatory mechanism that accounts for numerous craniofacial abnormalities, common being orofacial clefts. Although cleft in the secondary palate accounts for one-third of orofacial clefts stills remains an under-researched domain. Hence, in this work, the authors put forth two non-syndromic, asymptomatic cleft uvulae reported among bimodal male patients of the Indian-Asiatic population who came up for dental screening. Most of the time, isolated\/asymptomatic cleft uvula patients will be reluctant to further investigations and treatment. Although bifid uvula looks benign in most patients, it may sometimes be associated with catastrophic complications. To conclude, whenever bifid uvula is an incidental finding, it is the responsibility of the healthcare worker to plan a thorough patient workup as a primary preventive measure to rule out any complications whenever feasible. It can help us overcome many future unforeseen sequelae and emergency management due to bifid uvula.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_464_22","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:07:24Z","timestamp":1689127644000},"page":"S806-S809","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Bifid Uvula\u2014An Enigma"],"prefix":"10.4103","volume":"15","author":[{"given":"Prathibha","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Basic Dental Sciences, College of Dentistry, Ajman University, Ajman, UAE"},{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtesam","family":"Khalil","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE"},{"name":"Department of Basic Dental Sciences, College of Dentistry, Ajman University, Ajman, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Bhavrao","family":"Desai","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE"},{"name":"Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir Rama","family":"Varma","sequence":"additional","affiliation":[{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, UAE"},{"name":"Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalithambigai","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Vivekananda Dental College for Women, Namakkal, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, SDM College of Dental Sciences and Hospital, (A Constituent Unit of Shri Dharmasthala Manjunatheshwara University) Dharwad, Karnataka state, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulakshana","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Government Dental College and Research Institute, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2273.2004.00886.x","article-title":"Why do we have a uvula?:Literature review and a new theory","volume":"29","author":"Back","year":"2004","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"(suppl_1)","key":"R2-20240829","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1093\/hmg\/ddh052","article-title":"Genetics of cleft lip and palate:Syndromic genes contribute to the incidence of non-syndromic clefts","volume":"13","author":"Stanier","year":"2004","journal-title":"Human Mol Genet"},{"key":"R3-20240829","doi-asserted-by":"crossref","DOI":"10.1097\/01.EEM.0000414681.09689.6e","article-title":"Say Ah:The unexpected uvula","volume":"34","author":"Wiske","year":"2012","journal-title":"Emerg Med News"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.bjorl.2017.08.004","article-title":"Incidence of bifid uvula and its relationship to submucous cleft palate and a family history of oral cleft in the Brazilian population","volume":"84","author":"Sales","year":"2018","journal-title":"Braz J Otorhinolaryngol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1212\/NXG.0000000000000625","article-title":"Novel mutation of the TGF-b 3 protein (Loeys-Dietz Type 5) associated with aortic and carotid dissections:Case report","volume":"7","author":"Hussein","year":"2021","journal-title":"Neurol Genet"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1590\/S1806-83242012005000016","article-title":"TGFA\/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil","volume":"26","author":"Souza","year":"2012","journal-title":"Braz Oral Res"},{"key":"R7-20240829","first-page":"645","article-title":"Morphological variations of uvula:A clinical study based on Chennai population","volume":"5","author":"Gopal","year":"2016","journal-title":"World J Pharm Sci"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"592271","DOI":"10.3389\/fcell.2020.592271","article-title":"Non-syndromic cleft palate:An overview on human genetic and environmental risk factors","volume":"8","author":"Martinelli","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"017","DOI":"10.17352\/2455-4634.000027","article-title":"Bifid Uvula in three members of a family","volume":"3","author":"Khasbage","year":"2017","journal-title":"Int J Oral Craniofac Sci"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.radcr.2021.12.024","article-title":"Loeys-Dietz syndrome:Case report and review of the literature","volume":"17","author":"Malyuk","year":"2022","journal-title":"Radiol Case Rep"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3390\/genes12101462","article-title":"Differential diagnosis between Marfan syndrome and Loeys\u2013Dietz syndrome type 4:A novel chromosomal deletion covering TGFB2","volume":"12","author":"Nistri","year":"2021","journal-title":"Genes"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4103\/1658-354X.121061","article-title":"Bifid uvula:Anesthetist don't take it lightly!","volume":"7","author":"Samanta","year":"2013","journal-title":"Saudi J Anaest"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1056\/NEJMicm070582","article-title":"Bifid uvula and aortic aneurysm","volume":"359","author":"Vilacosta","year":"2008","journal-title":"N Engl J Med"},{"key":"R14-20240829","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/jamadermatol.2013.1128","article-title":"Uvulectomies and associated complications","volume":"149","author":"Jacobson","year":"2013","journal-title":"JAMA Dermatol"},{"key":"R15-20240829","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate:Understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_464_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:30:32Z","timestamp":1786725032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_464_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":15,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_464_22","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-10-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}