{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:20:06Z","timestamp":1789388406300,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Antidepressants have anti-inflammatory effects and boost immunity, and dentists should be aware. This case-control study included only those patients who consented to take part and had a ham-d score of at least 16 and a diagnosis of moderate-to-severe depression. Inclusion criteria included adults, those experiencing moderate to severe depression, taking fluoxetine or venlafaxine, and those with twenty or more teeth. Exclusion criteria included tobacco chewers, smokers, women expecting or nursing, periodontal treatment, antibiotics, anti-inflammatory medication, or vitamin\/nutritional supplements. Patients who had had surgery or other therapy were excluded from the study. Three groups of patients were created: Control, venlafaxine, and fluoxetine. A periodontist assisted in the dental examination, and indices were observed. The analysis was done using Statistical Package for the Social Sciences (SPSS) version 24.0. Number, percentage, mean, and standard deviation were used to present the values. Results showed that antidepressants may be a risk factor for periodontal health, with increased periodontal parameters, and concluded that It is crucial to frequently check the periodontal health of depressed people using fluoxetine or venlafaxine since these drugs put good periodontal tissues at risk.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_464_23","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:05:45Z","timestamp":1709219145000},"page":"S215-S218","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Association of the Antidepressants and the Periodontal Status: An Original Research"],"prefix":"10.4103","volume":"16","author":[{"given":"Rizleena","family":"Majeed","sequence":"first","affiliation":[{"name":"Department of Periodontology, Kannur Dental College, Anjarakandy, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna V.","family":"Sathi","sequence":"additional","affiliation":[{"name":"BDS, Government Dental College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruthika S.","family":"Patil","sequence":"additional","affiliation":[{"name":"Prosthodontics, Research Student Worker, Kornberg School of Dentistry, Temple University, Philadelphia, PA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Singh","sequence":"additional","affiliation":[{"name":"BDS Dentist, Dr. Neetu\u2019s Dental Clinic, Noida, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Duseja","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameswari","family":"Kondreddy","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry, AIMST University, Semeling, Bedong, Kedah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0757.2005.00137.x","article-title":"Effects of medications on the periodontal tissues in health and disease","volume":"40","author":"Seymour","year":"2006","journal-title":"Periodontology 2000"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0765.2006.00896.x","article-title":"Fundamental mechanisms of host immune responses to infection","volume":"41","author":"Azuma","year":"2006","journal-title":"J Periodontal Res"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1902\/jop.2009.080334","article-title":"Stress, depression, cortisol, and periodontal disease","volume":"80","author":"Rosania","year":"2009","journal-title":"J Periodontol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1592\/phco.24.6.621.34748","article-title":"Treatment of pain syndromes with venlafaxine","volume":"24","author":"Grothe","year":"2004","journal-title":"Pharmacotherapy"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2165\/00003088-199426030-00004","article-title":"Clinical pharmacokinetics of fluoxetine","volume":"26","author":"Altamura","year":"1994","journal-title":"Clin Pharmacokinet"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14219\/jada.archive.1964.0034","article-title":"The simplified oral hygiene index","volume":"68","author":"Greene","year":"1964","journal-title":"J Am Dent Assoc"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","article-title":"Periodontal disease in pregnancy I. 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