{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:04Z","timestamp":1787775844952,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To develop and validate a reliable, objective method for cervical vertebral bone age (CVBA) estimation using lateral cephalograms in a Maharashtrian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Gender-specific formulae for cervical vertebral bone age estimation were derived via stepwise regression using C3\/C4 measurements from lateral cephalograms of 1000 participants 1000 participants (500M\/500F, 9-20 years). Formulae were validated on an independent sample (100M\/100F). Hand-wrist radiographs were assessed using the Tanner-Whitehouse 3 (TW3) method. CVBA, TW3 bone age, and chronological age were compared using ANOVA, Tukey\u2019s test, and Pearson correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      Gender-specific CVBA formulae were generated. No significant differences were found between CVBA, TW3 bone age, and chronological age for males (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.393) or females (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.656). High correlations existed between CVBA, TW3 bone age, and chronological age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The derived formulae are valid and reliable for objective assessment of cervical vertebral bone age and skeletal maturation using lateral cephalograms in the studied Maharashtrian population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_471_25","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:00:42Z","timestamp":1746849642000},"page":"S597-S599","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Formula Based Model for Predicting Skeletal Maturation in Maharashtra"],"prefix":"10.4103","volume":"17","author":[{"given":"Prachi","family":"Gaonkar","sequence":"first","affiliation":[{"name":"Department of Orthodontics, NarsinhBhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"},{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kubavat","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, NarsinhBhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Shenava","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truppti P.","family":"Sonone","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmaya","family":"Hawaldar","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Terna Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1067\/mod.2000.105571","article-title":"Treatment timing for twin- block therapy","volume":"118","author":"Baccetti","year":"2000","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/j.sodo.2005.04.005","article-title":"The cervical vertebral maturation (CVM) method for the assessment of optimal treatment timing in dentofacial orthopedics","volume":"11","author":"Baccetti","year":"2005","journal-title":"Semin Orthod"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0889-5406(95)70157-5","article-title":"Skeletal maturation evaluation using cervical vertebrae","volume":"107","author":"Hassel","year":"1995","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ajodo.2005.01.031","article-title":"Chronological age and skeletal maturation of cervical vertebrae and hand-wrist - is there any relationship?","volume":"130","author":"Uysal","year":"2006","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S1678-77572007000200014","article-title":"Use of cervical vertebral dimensions for assessment of children growth","volume":"15","author":"Caldas","year":"2007","journal-title":"J Appl Oral Sci"},{"key":"R6-20250513","first-page":"16","article-title":"An improved version of the cervical vertebral maturation (CVM) method for assessment of mandibular growth","volume":"72","author":"Bacetti","year":"2002","journal-title":"Angle Orthod"},{"key":"R7-20250513","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1067\/mod.2002.126896","article-title":"Cervical vertebral bone age in girls","volume":"122","author":"Mito","year":"2002","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R9-20250513","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1148\/radiol.2493080468","article-title":"Racial differences in growth patterns of children assessed on the basis of bone age","volume":"250","author":"Zhang","year":"2009","journal-title":"Radiology"},{"key":"R10-20250513","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1590\/S1806-83242007000400009","article-title":"New formula to objectively evaluate skeletal maturation using lateral cephalometric radiographs","volume":"21","author":"Caldas","year":"2007","journal-title":"Braz Oral Res"},{"key":"R11-20250513","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0301-5742.175704","article-title":"Mehrotra AK Evaluation of skeletal maturity in North Indian patients using an objective method based on cervical vertebral bone age and assessment of its reliability as compared to hand\u2013wrist radiographic method","volume":"50","author":"Kumar","year":"2016","journal-title":"J Indian Orthod Soc"},{"key":"R12-20250513","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/ejo\/24.3.303","article-title":"Skeletal maturation determined by cervical vertebrae development","volume":"24","author":"Roman","year":"2002","journal-title":"Eur J Orthod"},{"key":"R13-20250513","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40510-020-00338-0","article-title":"Development and validation of a formula for objective assessment of cervical vertebral bone age","volume":"21","author":"Chandrasekar","year":"2020","journal-title":"Prog Orthod"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_471_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:39Z","timestamp":1787773419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_471_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":12,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_471_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-02-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}