{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:50Z","timestamp":1787840810110,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Head and neck cancer patients undergoing radiation therapy (RT) are at an increased risk of dental caries due to radiation-induced damage to salivary glands. This study aimed to compare the effectiveness of three interventions\u2014virgin coconut oil (VCO), casein phosphopeptide-amorphous calcium phosphate tooth mousse (TM), and amine fluoride mouthwash (MW)\u2014in preventing caries among head and neck cancer patients\u2019 post-radiation therapy.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A total of 102 head and neck cancer patients undergoing RT were enrolled. The participants were randomized to use one of three interventions: VCO, TM, or MW. Caries progression was assessed using the decayed-missing-filled-teeth (DMFT) index at baseline and after 6 months of RT. Differences in DMFT scores between the groups were analysed using statistical tests.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n At the 6-month follow-up, significant differences in DMFT scores were observed between the VCO and MW groups (\n P<\/jats:italic>\n = 0.012) and between the MW and TM groups (\n P<\/jats:italic>\n = 0.001). The TM group showed a significant reduction in caries progression compared to both the VCO and MW groups (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) tooth mousse was found to be the most effective in preventing new caries and slowing the progression of existing carious lesions in head and neck cancer patients undergoing radiation therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_478_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:06:12Z","timestamp":1738235172000},"page":"S4590-S4592","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["After Effects of Radiation on the Caries Status of Head and Neck Cancer Patients \u2212 A Six-Month Clinical Trial"],"prefix":"10.4103","volume":"16","author":[{"given":"Upasana","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, A.B.Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra N.","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, A.B.Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, A.B.Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallikarjuna Rao","family":"Koduru","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, K.S. Hegde Medical Institute of Health Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neevan","family":"Dsouza","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, K.S. Hegde Medical Institute of Health Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1470-2045(06)70658-1","article-title":"Radiation-related damage to dentition","volume":"7","author":"Kielbassa","year":"2006","journal-title":"Lancet Oncol"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/jcd.jcd_237_22","article-title":"Indices for the assessment of radiation-related caries","volume":"25","author":"Chopra","year":"2022","journal-title":"J Conserv Dent"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1102\/1470-7330.2004.0003","article-title":"Intensity-modulated radiotherapy\u2014what is it?","volume":"4","author":"Taylor","year":"2004","journal-title":"Cancer Imaging"},{"key":"R5-20250130","first-page":"1535","article-title":"The effect of casein phosphopeptide amorphous calcium phosphate fluoride paste (CPP-ACPF) on oral and salivary conditions of patients undergoing chemotherapy:A randomized controlled clinical trial","volume":"7","author":"Banava","year":"2015","journal-title":"Electron Phys"},{"key":"R6-20250130","first-page":"62","article-title":"Effect of oil-pulling on oral microorganisms in biofilm models","volume":"2","author":"Thaweboon","year":"2011","journal-title":"Asia J Public Health"},{"key":"R7-20250130","first-page":"63","article-title":"Effect of oil-pulling on dental caries causing bacteria","volume":"2","author":"Anand","year":"2008","journal-title":"Afr J Microbiol Res"},{"key":"R8-20250130","first-page":"38","article-title":"Virgin coconut oil process and economics","volume":"42","author":"Manikantan","year":"2015","journal-title":"Beverage Food World"},{"key":"R9-20250130","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00784-014-1318-y","article-title":"Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients","volume":"19","author":"Sim","year":"2015","journal-title":"Clin Oral Investig"},{"key":"R10-20250130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5005\/jp-journals-10005-1295","article-title":"Comparative evaluation of the effects of fluoride mouthrinse, herbal mouthrinse and oil pulling on the caries activity and Streptococcus mutans count using oratest and dentocult SM strip mutans kit","volume":"8","author":"Jauhari","year":"2015","journal-title":"Int J Clin Pediatr Dent"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_478_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:22Z","timestamp":1787837362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_478_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_478_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-04-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}