{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:50Z","timestamp":1787071610430,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Leukemia and its treatment compromise oral health, increasing periodontal disease risk in children. This study evaluated the long-term effects of periodontal interventions in children with leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed records of 85 children with leukemia receiving periodontal treatment at People\u2019s Dental Academy (2010\u20132020). Data included demographics, leukemia subtype (Acute Lymphoblastic Leukemia [ALL], Acute Myeloid Leukemia [AML], others), chemotherapy, Hematopoietic Stem Cell Transplantation [HSCT] history, periodontal diagnosis (gingivitis, periodontitis), interventions (scaling\/root planing, surgery), and clinical parameters (Pocket Depth [PD], Clinical Attachment Level [CAL], Bleeding on Probing [BOP], radiographic bone loss) at baseline, one, three, and five years. Patients with \u2265 three-year follow-up were included. Data were analyzed using descriptive statistics and repeated measures analysis of variance (ANOVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 45 ALL, 30 AML, and 10 other leukemia subtypes. At baseline, 70% had gingivitis, 30% periodontitis. Scaling\/root planing was most common. At one year, PD (3.2 mm to 2.5 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and BOP (60% to 25%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) significantly decreased. Improvements were maintained at three years (PD 2.2 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01 vs 1 year) and five years. HSCT patients showed similar improvements. No significant differences existed between leukemia subtypes. One patient experienced minor gingival recession post-surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Even after chemotherapy or HSCT, periodontal interventions sustain long-term periodontal health in children with leukemia. The importance of maintaining, as well as comprehensive oral health care and periodontal therapy stares at us from the five-year follow-up data. These results also illustrate the scant literature available on the long-term periodontal effects on these patients, pertaining to integrated dental practices. Further longitudinal research is warranted to confirm these results and identify additional risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_490_25","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:00:16Z","timestamp":1758733216000},"page":"S2193-S2195","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Outcomes of Periodontal Interventions in Children with Leukemia: A Retrospective Analysis"],"prefix":"10.4103","volume":"17","author":[{"given":"Anuj Singh","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Periodontology, People\u2019s Dental Academy, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Autonomous State Medical College, Akbarpur, Kanpur Dehat, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth Shailesh","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. N. D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran B.","family":"Suradkar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Bharti Vidyapeeth Dental College and Hospital, Navi, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maharishi Markandeshwar College of Dental Sciences and Research MM (DU), Mullana, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, College of Dental Science and Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Laddha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dr R R Kambe Dental College and Hospital, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases:A global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"104948","DOI":"10.1016\/j.archoralbio.2020.104948","article-title":"Oral health status of patients with leukemia:A systematic review with meta-analysis","volume":"120","author":"Angst","year":"2020","journal-title":"Arch Oral Biol"},{"key":"R3-20250930","first-page":"399","article-title":"Gingivitis and anti-neutrophil cytoplasmic antibodies in children and adolescents suffering from Leukemia","volume":"9","author":"Viera","year":"2004","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.3390\/ijms25116115","article-title":"The bloody crossroads:Interactions between periodontitis and hematologic diseases","volume":"25","author":"\u0141obacz","year":"2024","journal-title":"Int J Mol Sci"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.21873\/anticanres.13498","article-title":"Induction of non-apoptotic cell death by adrenergic agonists in human oral squamous cell carcinoma cell lines","volume":"39","author":"Uchida","year":"2019","journal-title":"Anticancer Res"},{"key":"R6-20250930","first-page":"502","article-title":"Treatment strategies for periodontitis patients with systemic disease","volume":"41","author":"Lin","year":"2023","journal-title":"Hua Xi Kou Qiang Yi Xue Za 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burden of hematologic malignancies and evolution patterns over the past 30 years","volume":"13","author":"Zhang","year":"2023","journal-title":"Blood Cancer J"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_490_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:49:29Z","timestamp":1787068169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_490_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"Suppl 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