{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:17Z","timestamp":1787840777605,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Alveolar bone resorption poses a significant challenge in rehabilitating edentulous patients. Ridge augmentation materials can stimulate bone growth in deficient areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To evaluate the biocompatibility and osteoconductivity of maxibloc bone grafts in rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Maxibloc was packed into bony voids created surgically in the mandible and femur of rabbits, which were sacrificed at the fourth, eighth, and twelfth weeks. Radiography and histopathology evaluations assessed the osteoconductivity; hematology and toxicology evaluations assessed the biocompatibility of maxibloc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Radiography revealed bone formation and homogenization without osteolysis. Histopathology revealed new bone formation with osteoblasts, fibrous and collagen tissue, cartilage formation, and no foreign body reaction or inflammation. Hematology revealed stable hemoglobin concentration, white blood cell count, eosinophil count, and absence of leucocytosis. Toxicology revealed elevated mortality rates at higher doses, whereas lower doses were safe. Animals exhibited no signs of systemic toxicity or behavioral changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Maxibloc has demonstrated biocompatibility and osteoconductivity, presenting as a promising alloplastic bone graft.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_505_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:03:34Z","timestamp":1738235014000},"page":"S4349-S4353","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Maxibloc Bone Grafts Biocompatibility and Osteoconductivity: An Animal Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Suja","family":"Joseph","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Travancore Dental College, Kerala University of Health Sciences, Kollam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Pushpagiri College of Dental Sciences, Kerala University of Health Sciences, Thiruvalla, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel M.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Dental Restoration and Prosthodontics, College of Dentistry, Majmaah University, Al-Majmaah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Kuriakose","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Pushpagiri College of Dental Sciences, Kerala University of Health Sciences, Thiruvalla, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Z.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Dental Restoration and Prosthodontics, College of Dentistry, Majmaah University, Al-Majmaah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Yasodharan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Travancore Dental College, Kerala University of Health Sciences, Kollam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep C.","family":"Dathan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, Sri Sankara Dental College, Kerala University of Health Sciences, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Dr. Nazia\u2019s Dental Care, CSI Ascension Square, Logos Juction, Kottayam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","first-page":"1","article-title":"Bone grafting materials:A literature review","volume":"4","author":"Martineau","year":"2022","journal-title":"J MAR Dent Sci"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3452171","article-title":"Innovative biomaterials based on collagen-hydroxyapatite and doxycycline for bone regeneration","volume":"2016","author":"Mederle","year":"2016","journal-title":"Adv Mater Sci Eng"},{"key":"R3-20250130","first-page":"2383","article-title":"Alloplastic bone grafts in periodontal surgery","volume":"10","author":"Dhanvanth","year":"2018","journal-title":"Drug Invent Today"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0022-3913(85)90556-6","article-title":"Hydroxyapatite for alveolar ridge augmentation:Indications and problems","volume":"54","author":"Desjardins","year":"1985","journal-title":"J Prosthet Dent"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0030-4220(90)90001-9","article-title":"Histologic evaluation of the bone\/graft interface after mandibular augmentation with hydroxylapatite\/purified fibrillar collagen composite implants","volume":"70","author":"Mehlisch","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4103\/jisp.jisp_386_18","article-title":"Evaluation and comparison of hydroxyapatite crystals with collagen fibrils bone graft alone and in combination with guided tissue regeneration membrane","volume":"23","author":"Mehrotra","year":"2019","journal-title":"J Indian Soc Periodontol"},{"key":"R7-20250130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J Pharmacol Pharmacother"},{"key":"R8-20250130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/1735-3327.92960","article-title":"Rabbit as an animal model for experimental research","volume":"9","author":"Mapara","year":"2012","journal-title":"Dent Res J (Isfahan)"},{"key":"R9-20250130","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1590\/0103-6440201601028","article-title":"Physico-chemical and histomorphometric evaluation of zinc-containing hydroxyapatite in rabbits calvaria","volume":"27","author":"Suruagy","year":"2016","journal-title":"Braz Dent J"},{"key":"R10-20250130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1515\/intox-2017-0006","article-title":"Animal tests for anxiety-like and depression-like behavior in rats","volume":"10","author":"Belovicova","year":"2017","journal-title":"Interdiscip Toxicol"},{"key":"R11-20250130","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0278-2391(86)80073-8","article-title":"Tissue response in dogs to dense hydroxylapatite implantation in the femur","volume":"44","author":"Gumaer","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"R12-20250130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00223-017-0294-z","article-title":"Histological evaluation of bone repair with hydroxyapatite:A systematic review","volume":"101","author":"Oliveira","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"R13-20250130","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.3390\/ma13214902","article-title":"Evaluation of osteoconduction of a synthetic hydroxyapatite\/\u03b2-tricalcium phosphate block fixed in rabbit mandibles","volume":"13","author":"Pires","year":"2020","journal-title":"Materials (Basel)"},{"key":"R14-20250130","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0278-2391(83)90190-8","article-title":"Histologic study of hydroxyapatite as an implant material for mandibular augmentation","volume":"41","author":"Chang","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"R15-20250130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0278-2391(87)90361-2","article-title":"Histologic study of tissue response to implanted hydroxylapatite in two patients","volume":"45","author":"Chao","year":"1987","journal-title":"J Oral Maxillofac Surg"},{"key":"R16-20250130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0142-9612(90)90008-E","article-title":"Quantitative study on osteoconduction of apatite-wollastonite containing glass ceramic granules, hydroxyapatite granules, and alumina granules","volume":"11","author":"Ono","year":"1990","journal-title":"Biomaterials"},{"key":"R17-20250130","first-page":"22808000221119650","article-title":"Comparative evaluation of two collagen-based biomaterials with different compositions used for bone graft:An experimental animal study","volume":"20","author":"Gehrke","year":"2022","journal-title":"J Appl Biomater Funct Mater"},{"key":"R18-20250130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/jfb13010028","article-title":"A comparative study of two bone graft substitutes-InterOss collagen and OCS-B collagen","volume":"13","author":"Jain","year":"2022","journal-title":"J Funct Biomater"},{"key":"R19-20250130","doi-asserted-by":"crossref","first-page":"201812002","DOI":"10.5542\/LDJ.v8i0.201812002","article-title":"Small things have a big impact:New trends in implant dentistry","volume":"8","author":"Joseph","year":"2018","journal-title":"Libyan Dent J"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_505_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:28:45Z","timestamp":1787837325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_505_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":19,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_505_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-05-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}