{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:05:02Z","timestamp":1791828302407,"version":"4.3.4"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n \n The\n Vitis vinifera<\/jats:italic>\n , also known as grapevine, is one of the most widely grown fruit crops in the world and is renowned for producing wine and grapes. Other than their importance in gastronomy and ecology, certain sections of the\n V. vinifera<\/jats:italic>\n plant have shown promising bioactive qualities. The numerous phytochemicals in this plant, including flavonoids, stilbenes, and phenolic acids, are what gives its antibacterial and antifungal properties though the antimicrobial properties of seed extract have to be studied, however in this present study we focus on screening and its biological compatibility of seed extracts of\n V. vinifera<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n The commercial power of seed (\n V. vinifera<\/jats:italic>\n ) obtained from local market near Poonamallee, Chennai, India. and the extraction of crude metabolites was done by direction extraction method, the antimicrobial activity was done by well diffusion method, and Minimum Inhibitory concentration was done by CLSI guideline. To check the biocompatibility of crude metabolites was done by hemolytic assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Studies have demonstrated that grapevine extracts and their separated components have potent antibacterial and antifungal effects against a variety of pathogenic microorganisms, including bacterial strains that are resistant to antibiotics. The Minimum Inhibitory Concentration of the plant\u2019s extracts have demonstrated potential 128 \u00b5g\/mL for\n S. aureus<\/jats:italic>\n , and 256 \u00b5g\/mL\n E. faecalis<\/jats:italic>\n and\n C. albicans<\/jats:italic>\n as the best inhibitory concentration. The biological compatibility of crude metabolites shows 3 % of lysis at 512 \u00b5g\/mL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n V. vinifera<\/jats:italic>\n is a prospective source for the creation of novel antimicrobial drugs because of its antibacterial capabilities. To completely understand the chemicals\u2019 mode of action and to create efficient treatments for microbial illnesses, more research is necessary.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_521_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:25:51Z","timestamp":1713270351000},"page":"S1186-S1190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial Activity of Crude Metabolites of Vitis vinifera using Methanol Extract against the Clinical Pathogens"],"prefix":"10.4103","volume":"16","author":[{"given":"Karunanithi","family":"Karkuzhali","sequence":"first","affiliation":[{"name":"Department of Microbiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Chennai, Tamil Nadu, 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