{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:57:03Z","timestamp":1787849823187,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>In periodontal diseases, bacteria and microbes serve as the primary pathogens that initiate the condition, while the host refers to the body that hosts these microorganisms. Host modulation therapy is a drug-based treatment that can be used along with systematic periodontal therapy to help the disease get better and stop tissue damage. There is a new way to treat periodontitis called \u201cHost-Modulation Therapy\u201d (HMT). It involves reducing the bacteria biofilm through daily good oral hygiene and regular scaling and root planing (SRP). Using host modulation therapies to lower inflammation, restore microbiome balance, and change the immune response of the host holds a lot of promise for better periodontal disease treatment. This review examines host modulation in treating and preventing periodontal diseases. The review encompasses a variety of studies that evaluate pharmaceutical agents, probiotics, and immunomodulatory methods.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_537_25","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:00:23Z","timestamp":1755777623000},"page":"S2052-S2054","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Periodontal Diseases and Host Modulation Therapies"],"prefix":"10.4103","volume":"17","author":[{"given":"Abdulaziz","family":"Alsakr","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1996.1.1.1","article-title":"Periodontal diseases:Epidemiology","volume":"1","author":"Papapanou","year":"1996","journal-title":"Ann Periodontol"},{"key":"R2-20250930","first-page":"1237","article-title":"Research, science and therapy committee of the American academy of periodontology. 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