{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:47Z","timestamp":1787776007788,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of &lt;0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_552_25","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:05:28Z","timestamp":1760457928000},"page":"102-104","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental Injuries: A Database Research"],"prefix":"10.4103","volume":"18","author":[{"given":"Shilpa","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Changani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjum","family":"Patan","sequence":"additional","affiliation":[{"name":"BDS, Mamata Dental College, Khammam, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil M.","family":"Managutti","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"R1-20260330","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cjtee.2023.05.003","article-title":"Impact of dental and orofacial trauma on oral health-related quality of life in adults: A systematic review","volume":"27","author":"Verma","year":"2024","journal-title":"Chin J Traumatol"},{"key":"R2-20260330","doi-asserted-by":"crossref","first-page":"101542","DOI":"10.1016\/j.tice.2021.101542","article-title":"Differentiation of human dental pulp stem cells into functional motor neuron: In vitro and ex vivo 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Biosci"},{"key":"R9-20260330","doi-asserted-by":"crossref","first-page":"1369505","DOI":"10.3389\/fphar.2024.1369505","article-title":"Editorial: Biomaterials used in tissue engineering for the restoration of ocular disorders","volume":"15","author":"Rodr\u00edguez-Lorenzo","year":"2024","journal-title":"Front Pharmacol"},{"key":"R10-20260330","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/biom12020285","article-title":"Biomolecule-mediated therapeutics of the dentin-pulp complex: A systematic review","volume":"12","author":"Machla","year":"2022","journal-title":"Biomolecules"},{"issue":"S10","key":"R11-20260330","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.53730\/ijhs.v8nS1.15031","article-title":"Innovative approaches in regenerative endodontics: A review of current literature","volume":"6","author":"Almoharib","year":"2022","journal-title":"Int J Health Sci"}],"container-title":["Journal of Pharmacy and Bioallied 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