{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:48Z","timestamp":1786653648883,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hygrophila auriculata (Acanthaceae family) and Cordia macleodii (Boraginaceae family) are two famous Indian plants that had until been unrecognized for their antihyperglycemic effects. This study examined the antihyperglycemic effect of metformin in a rat model of diabetes caused by the alloxan method for dried flower powder of H. auriculata and C. macleodii, both alone and in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Rat weights ranged from 150-200 g, housed under controlled conditions (25-26\u00b0C, 50-55% humidity, 12-hour light\/dark cycle) with standard diet and water access. Fresh flowers of H. auriculata and C. macleodii were collected, dried, and powdered. The powders were macerated in methanol, evaporated, and further processed. Acute toxicity was assessed by administering flower powder to rats in doses from 5 mg\/kg to 5,000 mg\/kg, determining LD50 values per OECD guidelines. Anti-hyperglycemic effects were tested in alloxan-induced diabetic rats, with blood glucose levels measured at intervals after oral administration of the flower powders. The hypoglycemic potential was evaluated using the area under the curve (AUC) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five hours after oral treatment, the investigation showed that a mixture of dried flower powder of H. auriculata and C. macleodii significantly reduced blood sugar levels. A key role in modulating the pharmacological action is played by the components derived from plants, including alkaloids and flavonoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study will provide light on new avenues for research into the therapeutic treatment of diabetes mellitus via the development of innovative herbal formulations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_555_24","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T02:00:13Z","timestamp":1723514413000},"page":"S3132-S3135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Antihyperglycemic Potential of Dried Powder Combination of Hygrophila auriculata and Cordia macleodii: In Vivo Study in Sprague Dawley Rats"],"prefix":"10.4103","volume":"16","author":[{"given":"Farooq M.","family":"Almutairi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, University of Hafr AlBatin, Hafr AlBatin, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"e0250405","DOI":"10.1371\/journal.pone.0250405","article-title":"Total polyphenols and antihyperglycemic activity of aqueous fruits extract of Abelmoschus esculentus:Modeling and optimization of extraction conditions","volume":"16","author":"Peter","year":"2021","journal-title":"PLoS One"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"212","DOI":"10.14715\/cmb\/2021.67.1.30","article-title":"Evaluation of antihyperglycemic activity of plants in northeast mexico","volume":"67","author":"Adame-Miranda","year":"2021","journal-title":"Cell Mol Biol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"107","DOI":"10.22270\/jddt.v10i3.4078","article-title":"Antihyperglycemic activity of total extract and fractions of Anogeissus leiocarpus","volume":"10","author":"Motto","year":"2020","journal-title":"J Drug Deliv Ther"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3390\/pharmaceutics13122019","article-title":"Antihyperglycemic effect of lavandula pedunculata:in vivo, in vitro and ex vivo approaches","volume":"13","author":"Boutahiri","year":"2021","journal-title":"Pharmaceutics"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"110082","DOI":"10.1016\/j.foodres.2020.110082","article-title":"Antihyperglycemic activity of crude extract and isolation of phenolic compounds with antioxidant activity from Moringa oleifera Lam. Leaves grown in Southern Brazil","volume":"141","author":"Oldoni","year":"2021","journal-title":"Food Res Int"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/DMSO.S266794","article-title":"Evaluation of antihyperglycemic effect of extract of moringa stenopetala (Baker f.). aqueous leaves on alloxan-induced diabetic rats","volume":"14","author":"Woldekidan","year":"2021","journal-title":"Diabet Metab Synd Obes"},{"key":"R7-20241227","doi-asserted-by":"crossref","first-page":"e251046","DOI":"10.1590\/1519-6984.251046","article-title":"Anti-hyperglycemic and anti-hyperlipidemic effects of a methanolic extract of Debregeasia salicifolia in Alloxan-induced diabetic albino mice","volume":"84","author":"Khan","year":"2021","journal-title":"Braz J Biol"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3390\/nu14112338","article-title":"Antioxidant and antihyperglycemic effects of Ephedra foeminea aqueous extract in streptozotocin-induced diabetic rats","volume":"14","author":"Hajleh","year":"2022","journal-title":"Nutrients"},{"key":"R9-20241227","first-page":"1725","article-title":"Potential of Hygrophila auriculata (Schumach.) Heine as a source of future anti-cancer drugs:A comprehensive review","volume":"6","author":"Saha","year":"2017","journal-title":"J Pharmacogn Phytochem"},{"key":"R10-20241227","first-page":"216","article-title":"Phytochemical and pharmacological investigation of Cordia macleodii Hook","volume":"6","author":"Pandey","year":"2020","journal-title":"World J Pharm Life Sci"},{"key":"R11-20241227","doi-asserted-by":"crossref","first-page":"100118","DOI":"10.1016\/j.metop.2021.100118","article-title":"Antihyperglycemic and hypoglycemic activities of the aqueous leaf extract of Rubus Erlangeri Engl (Rosacea) in mice","volume":"11","author":"Ayele","year":"2021","journal-title":"Metab Open"},{"key":"R12-20241227","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jep.2005.09.030","article-title":"Action of Hygrophila auriculata against streptozotocin-induced oxidative stress","volume":"104","author":"Vijayakumar","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"R13-20241227","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.indcrop.2018.04.037","article-title":"Phytochemical analysis and biological evaluation of three selected Cordia species from Panama","volume":"120","author":"Marini","year":"2018","journal-title":"Indus Crops Prod"},{"key":"R14-20241227","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/jphp.12715","article-title":"Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)","volume":"69","author":"Oza","year":"2017","journal-title":"J Pharm Pharmacol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_555_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:30Z","timestamp":1786650030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_555_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":14,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_555_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"assertion":[{"value":"2024-05-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}