{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:35:58Z","timestamp":1788867358251,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    Nanoparticles prepared from bio-reduction agents are of keen interest to researchers around the globe due to their ability to mitigate the harmful effects of chemicals. In this regard, the present study aims to synthesize copper oxide nanoparticles (CuO NPs). CuNPs show a characteristic absorption peak at 347 nm, while SEM reveals the spherical but agglomerated shape of CuNPs of the size within the range of 51.26\u201356.66 nm. The crystallite size measured by using XRD was found to be within a range of 23.38\u201346.64 nm for ginger-doped CuO and 26\u201356 nm for garlic-doped CuO. The X-ray diffraction analysis shows the crystalline structure of copper nanoparticles with prominent peaks. Bragg\u2019s reflection of copper nanoparticles shows diffraction peaks around 2\u03b8 =43.4\u00b0, 50.3\u00b0, and 74.39\u00b0, representing [111], [200], and [220] crystallographic planes of face-centered cubic (fcc). The synthesized CuO NPs tested antibacterial properties against various strains of microorganisms, including\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , 25 \u03bcg\/mL 2.3 \u00b1 0.21 and 100 \u03bcg\/mL 6.5 \u00b1 0.17,\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    , 25 \u03bcg\/mL 2.3 \u00b1 0.29 and 100 \u03bcg\/mL 11.5 \u00b1 1.17,\n                    <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                    , 25 \u03bcg\/mL 01.05 \u00b1 0.21 and 100 \u03bcg\/mL 15.8 \u00b1 0.17,\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    ). The short novelty of\n                    <jats:italic toggle=\"yes\">Azadirachta indica<\/jats:italic>\n                    lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_562_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:29:13Z","timestamp":1713270553000},"page":"S1249-S1255","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological Effect of Copper Oxide Nanoparticles of Azadirachta indica Leaf Extract and Application for its Antibacterial Properties"],"prefix":"10.4103","volume":"16","author":[{"given":"RK","family":"Naven Kumar","sequence":"first","affiliation":[{"name":"Natural Products and Nanobiotechnology Research Lab, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha Deemed to be University), Thandalam, Chennai Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhagu Madhavan","family":"Sivalingam","sequence":"additional","affiliation":[{"name":"Natural Products and Nanobiotechnology Research Lab, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha Deemed to be University), Thandalam, Chennai Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arockia","family":"Alex","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha Deemed to be University), Thandalam, Chennai Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Brahma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha Deemed to be University), Thandalam, Chennai Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1166\/jbn.2009.038","article-title":"Antibacterial applications of silver nanoparticles synthesized by aqueous extract of Azadirachta indica (Neem) leaves","volume":"5","author":"Tripathi","year":"2009","journal-title":"J Biomed Nanotechnol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free 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