{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:45Z","timestamp":1787070825806,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Opioid-based analgesia has been a cornerstone of postoperative pain management. However, its extensive use is associated with significant risks, including dependency and adverse side effects. Multimodal anesthesia (MMA) strategies, combining various pharmacological and non-pharmacological interventions, have been proposed to reduce opioid use, while maintaining effective analgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical research was led with subjects undergoing elective surgeries. Patients were divided into two groups: one receiving traditional opioid-based anesthesia (TOA) and the other utilizing MMA. Pain scores, recovery time, and opioid consumption were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients in the MMA group demonstrated significantly lower opioid consumption (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and improved recovery times compared to the traditional group. Pain scores were comparable across both groups, with a slight advantage observed in the MMA cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MMA effectively reduces opioid requirements without compromising pain control, potentially enhancing postoperative recovery. Further studies are warranted to establish long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_563_25","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T12:01:28Z","timestamp":1761912088000},"page":"131-133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["ENHANCED: Assessment of Effects of Reducing Opioid Use Through Multimodal Anesthesia in Recovery Protocols: A Clinical Study"],"prefix":"10.4103","volume":"18","author":[{"given":"Adeeba","family":"Shabnam","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Katuri Medical College, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Addla","sequence":"additional","affiliation":[{"name":"Medical Student, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etikala Pravallika","family":"Reddy","sequence":"additional","affiliation":[{"name":"Medical Student, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulla Mohammad Usman","family":"Nalband","sequence":"additional","affiliation":[{"name":"4year Medical Student, MBChB, University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mujoo","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Radiology, Department of Oral Medicine and Radiology, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhe Shyam","family":"Singh","sequence":"additional","affiliation":[{"name":"Intern, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"R1-20260330","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMra1507771","article-title":"Opioid abuse in chronic pain--misconceptions and mitigation strategies","volume":"374","author":"Volkow","year":"2016","journal-title":"N Engl J Med"},{"issue":"2 Suppl","key":"R2-20260330","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.36076\/ppj.2008\/11\/S63","article-title":"Therapeutic opioids: A ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids","volume":"11","author":"Manchikanti","year":"2008","journal-title":"Pain Physician"},{"key":"R3-20260330","first-page":"1048","article-title":"The value of \u201cmultimodal\u201d or \u201cbalanced analgesia\u201d in postoperative pain treatment","volume":"77","author":"Kehlet","year":"1993","journal-title":"Anesth Analg"},{"key":"R4-20260330","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0140-6736(11)60245-6","article-title":"Treatment of acute postoperative pain","volume":"377","author":"Wu","year":"2011","journal-title":"Lancet"},{"key":"R5-20260330","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jpain.2015.12.008","article-title":"Management of postoperative pain: A clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists\u2019 Committee on regional anesthesia, executive committee, and administrative council","volume":"17","author":"Chou","year":"2016","journal-title":"J Pain"},{"key":"R6-20260330","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jvs.2019.01.050","article-title":"A systematic review of enhanced recovery after surgery for vascular operations","volume":"70","author":"McGinigle","year":"2019","journal-title":"J Vasc Surg"},{"key":"R7-20260330","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/aas.12601","article-title":"Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 1: Pathophysiological considerations","volume":"59","author":"Scott","year":"2015","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_563_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:37:15Z","timestamp":1787067435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_563_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_563_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"2025-02-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}