{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:35:34Z","timestamp":1790908534708,"version":"4.1.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>\n                    Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, accounting for nearly 90% of all oral cancers. It remains a significant global health concern due to the high morbidity and mortality, often diagnosed at advanced stages despite advancements in diagnostic tools such as biopsy, imaging, and molecular markers. OSCC is driven by genetic and molecular alterations, including\n                    <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                    mutations, EGFR overexpression, and dysregulated signaling pathways that promote tumor progression. While treatment primarily includes surgery, radiotherapy, and chemotherapy, emerging approaches such as targeted therapy and immunotherapy are showing promise. However, challenges such as recurrence, metastasis, and treatment resistance persist. Improving early detection strategies, identifying novel biomarkers, and incorporating precision medicine approaches are crucial for enhancing survival outcomes and quality of life in OSCC patients.\n                  <\/jats:p>","DOI":"10.4103\/jpbs.jpbs_593_25","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T02:32:22Z","timestamp":1746066742000},"page":"S204-S206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["A Narrative Review on Oral Squamous Cell Carcinoma"],"prefix":"10.4103","volume":"17","author":[{"given":"Shrikanth","family":"Muralidharan","sequence":"first","affiliation":[{"name":"Department of Research, NIN, Pune Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monali","family":"Nikalje","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Symbiosis Medical College for Women (SMCW) and Symbiosis University Hospital and Research Centre (SUHRC), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulsi","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Symbiosis Medical College for Women (SMCW) and Symbiosis University Hospital and Research Centre (SUHRC), Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy Annie","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Periodontology, M A Rangoonwala College of Dental Sciences and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit V","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Microbiology, M A Rangoonwala College of Dental Sciences and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Bangera","sequence":"additional","affiliation":[{"name":"Research Officer, Department of Yoga and Naturopathy, Central Council for Research in Yoga and Naturopathy, Under Ministry of Ayush, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"R1-20250513","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.oraloncology.2018.10.034","article-title":"Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma","volume":"87","author":"Gr\u00e9goire","year":"2018","journal-title":"Oral Oncol"},{"key":"R2-20250513","first-page":"315","article-title":"Notch1 in oral squamous cell carcinoma","volume":"32","author":"Yoshida","year":"2017","journal-title":"Histol Histopathol"},{"key":"R3-20250513","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/jop.12791","article-title":"Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma: Systematic review and meta-analysis","volume":"50","author":"Gaba","year":"2021","journal-title":"J Oral Pathol Med"},{"key":"R4-20250513","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/jamaoncol.2017.4777","article-title":"Association of oral microbiome with risk for incident head and neck squamous cell cancer","volume":"4","author":"Hayes","year":"2018","journal-title":"JAMA Oncol"},{"key":"R5-20250513","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tvjl.2012.02.023","article-title":"Oral squamous cell carcinoma: Like owner, like cat","volume":"193","author":"Snyder","year":"2012","journal-title":"Vet J"},{"key":"R6-20250513","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ejso.2018.01.004","article-title":"Follow-up after curative treatment for oral squamous cell carcinoma. 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