{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:55Z","timestamp":1786653655943,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Posterior capsule opacification (PCO) is the most common cause of vision reduction following successful cataract surgery. It is a dynamic process caused by the migration and proliferation of residual lens epithelial cells on the posterior capsule, leading to visual impairment. The standard treatment for PCO is neodymium: yttrium\u2013aluminum\u2013garnet (Nd: YAG) laser capsulotomy. This study aims to compare the efficacy and safety of Bimatoprost 0.03% and Brimonidine 0.2% in preventing intraocular pressure (IOP) elevation post-Nd: YAG laser capsulotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was conducted over a year at the Government Medical College, Jammu. 400 patients with PCO post extracapsular cataract extraction were randomly divided into two groups. Group A received 1 drop of Bimatoprost 0.03% and Group B received 1 drop of Brimonidine 0.2%, both administered 1 hour before Nd: YAG laser capsulotomy. Intraocular pressure was measured using Goldmann applanation tonometry before treatment and at intervals of 1 hour, 3 hours, 24 hours, 3 days, and 7 days post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age of patients was approximately 65 years with no significant difference between groups. The baseline IOP was similar across both groups. At 1 hour post-capsulotomy, Group A showed a mean IOP increase of 2.2 mmHg, while Group B showed an increase of 3.6 mmHg. At 24 hours, the IOP in Group A returned to baseline levels, whereas Group B still exhibited a slight elevation. No significant adverse effects were reported in either group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bimatoprost 0.03% is more effective in preventing IOP elevation post Nd: YAG laser capsulotomy compared to Brimonidine 0.2%. It also demonstrated a faster return to baseline IOP levels with fewer side effects. This suggests that Bimatoprost may be a preferable prophylactic treatment for managing post-capsulotomy IOP spikes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_605_24","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:42:09Z","timestamp":1724362929000},"page":"S3142-S3145","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Bimatoprost 0.03% and Brimonidine 0.2% in Managing Intraocular Pressure Elevation Following Nd:YAG Laser Capsulotomy for Posterior Capsule Opacification"],"prefix":"10.4103","volume":"16","author":[{"given":"Tulika","family":"Gupta","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Ophthalmology, FMHS, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupali","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Senior Resident, Department of Ophthalmology, FMHS, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikhar","family":"Ganjoo","sequence":"additional","affiliation":[{"name":"Professor and Head, Department of Dermatology, FMHS, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"R1-20241227","first-page":"60","article-title":"Posterior capsule opacification:A review of the aetiopathogenesis, experimental and clinical studies, and factors for prevention","volume":"46","author":"Peng","year":"1998","journal-title":"Indian J Ophthalmol"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0039-6257(92)90073-3","article-title":"Posterior capsule opacification","volume":"37","author":"Apple","year":"1992","journal-title":"Surv Ophthalmol"},{"key":"R3-20241227","first-page":"751","article-title":"Pseudophakic fibrous metaplasia. 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