{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:51Z","timestamp":1787071251287,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Potentially malignant disorders are highly prevalent in India. In this study, we assessed C-reactive protein (CRP) levels in patients with oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>Sixty-four patients (OSMF and OSCC) were undertaken and were classified into 3 groups, OSMF patients (Group I, 34), OSCC (Group II, 30), and healthy controls (Group III, 26). Immunoturbidimetry method was used for the estimation of CRP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Maximum cases in Group I was seen in the age group 40\u201360 years (males-10, females-3), Group II in the age group 40\u201360 years (males-11, females-5) and Group III (males-5, females-6). The mean CRP level in Group I was 6.12 \u00b1 4.5 mg\/l, in Group II was 28.4 \u00b1 21.5 mg\/l, and in Group III was 3.15 \u00b1 2.19 mg\/l. The difference was significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Authors found that OSMF and oral cancer patients had increased CRP levels as compared to healthy subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_607_20","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T07:46:24Z","timestamp":1622879184000},"page":"S748-S750","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of C-Reactive Protein Level in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma Patient"],"prefix":"10.4103","volume":"13","author":[{"given":"Geeta","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Sarjug Dental College, Darbhanga, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randhir","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Patna Dental College and Hospital, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharib Abdus","family":"Salam","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Patna Dental College and Hospital, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Shree Bankey Bihari Dental College, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant Kumar","family":"Tewari","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Nalanda Medical College and Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, I.T.S Dental College, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"R1-20241204","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3322\/canjclin.52.4.195","article-title":"Oral cancer and precancerous lesions","volume":"52","author":"Neville","year":"2002","journal-title":"CA Cancer J Clin"},{"key":"R2-20241204","first-page":"SR3","article-title":"C-reactive protein: An inflammatory marker with specific role in physiology, pathology, and diagnosis","volume":"2","author":"Chandrashekara","year":"2014","journal-title":"IJRCI"},{"key":"R3-20241204","doi-asserted-by":"crossref","first-page":"18284","DOI":"10.1038\/srep18284","article-title":"Smokeless tobacco consumption impedes metabolic, cellular, apoptotic and systemic stress pattern: A study on Government employees in Kolkata, India","volume":"5","author":"Biswas","year":"2015","journal-title":"Sci Rep"},{"key":"R4-20241204","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/1414-431X20143599","article-title":"Relationship of inflammatory markers and pain in patients with head and neck cancer prior to anticancer therapy","volume":"47","author":"Oliveira","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"R5-20241204","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijom.2017.06.017","article-title":"Clinical significance of preoperative serum C-reactive protein in oral squamous cell carcinoma","volume":"47","author":"Acharya","year":"2018","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R6-20241204","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3109\/10520295.2015.1077393","article-title":"Altered serum and salivary C-reactive protein levels in patients with oral premalignant lesions and oral squamous cell carcinoma","volume":"91","author":"Metgud","year":"2016","journal-title":"Biotech Histochem"},{"key":"R7-20241204","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.3748\/wjg.v12.i23.3746","article-title":"Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus","volume":"12","author":"Gockel","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R8-20241204","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02873502","article-title":"A report on clinical importance of serum glycoconjugates in oral cancer","volume":"5","author":"Baxi","year":"1990","journal-title":"Indian J Biochem"},{"key":"R9-20241204","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1200\/JCO.2008.19.8440","article-title":"Base line protein is associated with incident cancer and survival in patients with cancer","volume":"27","author":"Allin","year":"2009","journal-title":"J Clin Oncol"},{"key":"R10-20241204","first-page":"358","article-title":"Evaluation of serum C-reactive protein levels in oral premalignancies and malignancies: A comparative study","volume":"15","author":"Vankadara","year":"2018","journal-title":"J Dent (Tehran)"},{"key":"R11-20241204","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/jomfp.JOMFP_317_19","article-title":"Serum C-reactive protein in oral submucous fibrosis and oral squamous cell carcinoma: A cross-sectional study","volume":"24","author":"Gosavi","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"key":"R12-20241204","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0975-8844.157355","article-title":"Quantitative analysis of C-reactive protein in potentially malignant disorders: A pilot study","volume":"7","author":"Kaja","year":"2015","journal-title":"J Orofac Sci"},{"key":"R13-20241204","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.oraloncology.2005.08.005","article-title":"Oral submucous fibrosis: Review on aetiology and pathogenesis","volume":"42","author":"Tilakaratne","year":"2006","journal-title":"Oral Oncol"},{"key":"R14-20241204","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0970-9290.29877","article-title":"Prevalence of oral lesions in relation to habits: Cross-sectional study in South India","volume":"17","author":"Saraswathi","year":"2006","journal-title":"Indian J Dent Res"},{"key":"R15-20241204","first-page":"16","article-title":"Altered C-reactive protein levels in serum of oral pre cancer patients in comparison with healthy control","volume":"2","author":"Anand Kumar","year":"2011","journal-title":"Int J Oral Maxillofac Pathol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.JPBS_607_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:40Z","timestamp":1787067820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.JPBS_607_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":15,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_607_20","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-09-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}