{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:58Z","timestamp":1787070778762,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Introduction:<\/jats:title>\n Splenomegaly, often resulting from liver cirrhosis, leads to severe hematological and structural impairments. Conventional treatments offer limited efficacy, and alternative approaches are needed.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n This study investigates the therapeutic potential of\n Sharpunkha<\/jats:italic>\n (Tephrosia purpurea), a traditionally recognized hepatoprotective herb, in managing splenomegaly due to liver cirrhosis.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n An\n in vivo<\/jats:italic>\n experimental model was developed using thioacetamide-induced splenomegaly in Wistar albino rats, followed by the administration of\n Sharpunkha Panchanga Churna<\/jats:italic>\n and\n Sharpunkha Panchanga Kshara<\/jats:italic>\n . The study assessed anatomical and histological changes, liver function tests (LFT), and complete blood count (CBC) parameters. Results demonstrated that\n Sharpunkha Panchanga Kshara<\/jats:italic>\n exhibited superior efficacy in reducing splenic hyperplasia and hepatic fibrosis compared to\n Churna<\/jats:italic>\n , closely following the effects of Silymarin, the standard drug.\n <\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n \n Histological analysis confirmed improved spleen and liver architecture post-treatment. These findings validate the Ayurvedic reference of\n Sharpunkha<\/jats:italic>\n as \u201c\n Pleehashatru<\/jats:italic>\n \u201d and suggest its potential for clinical application.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Future research should focus on clinical trials to establish its therapeutic role in hepatosplenomegaly management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_628_25","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:01:32Z","timestamp":1769778092000},"page":"S81-S83","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Sharpunkha\u2019s Efficacy in Splenomegaly- A Research Report"],"prefix":"10.4103","volume":"18","author":[{"given":"Rajni K.","family":"Gurmule","sequence":"first","affiliation":[{"name":"Ph.D. Scholar, Deparment of Rachana Sharir, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav R.","family":"Sawarkar","sequence":"additional","affiliation":[{"name":"Professor, Deparment of Rachana Sharir, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12967-017-1214-8","article-title":"The spleen in liver cirrhosis: Revisiting an old enemy with novel targets","volume":"15","author":"Li","year":"2017","journal-title":"J Transl Med"},{"key":"R2-20260310","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1590-8658(02)80246-8","article-title":"Role of spleen enlargement in cirrhosis with portal hypertension","volume":"34","author":"Bolognesi","year":"2002","journal-title":"Dig Liver Dis"},{"key":"R3-20260310","first-page":"14","article-title":"Literary review -role of aahar vidhi given by acharya charaka in present era","volume":"9","author":"Rajni","year":"2023","journal-title":"Indian J Appl Res"},{"key":"R4-20260310","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4103\/0253-7613.129317","article-title":"Hepatoprotective activity of tephrosia purpurea against arsenic induced toxicity in rats","volume":"46","author":"Gora","year":"2014","journal-title":"Indian J Pharmacol"},{"key":"R5-20260310","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/ayu.AYU_281_19","article-title":"Efficacy of Sharapunkhadi powder (a polyherbal formulation) and lifestyle modification in the management of nonalcoholic fatty liver disease-A randomized placebo-controlled clinical trial","volume":"41","author":"Remya","year":"2020","journal-title":"Ayu"},{"key":"R6-20260310","doi-asserted-by":"crossref","first-page":"108","DOI":"10.30750\/ijpbr.2.1.18","article-title":"Tephrosia purpurea Linn (Sharpunkha, Wild Indigo): A review on phytochemistry and pharmacological studies","volume":"2","author":"Dalwadi","year":"2014","journal-title":"Indian J Pharm Biol Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_628_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:26Z","timestamp":1787067386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_628_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":6,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_628_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-02-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}