{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:04Z","timestamp":1787840524497,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dental implants are a reliable treatment for tooth replacement, with success dependent on osseointegration, implant stability, and bone density. Vitamin D3 plays a critical role in bone metabolism, influencing calcium absorption and bone mineralization. However, the effect of vitamin D3 supplementation on implant outcomes remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 20 patients with vitamin D deficiency (10-30 ng\/mL) were divided into two groups:<\/jats:p>\n                    <jats:p>\n                      All patients underwent standard implant placement. Crestal bone level and bone density were assessed using CBCT, and implant stability was measured using resonance frequency analysis (RFA) at baseline, 3 months, and 6 months postimplant placement. Data were analyzed using ANOVA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Implant stability improved significantly in Group A compared with Group B at 3 and 6 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Crestal bone loss was higher in Group B, but the difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.07). Bone density remained comparable between both groups at all time points (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 1.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D3 supplementation significantly enhances implant stability, suggesting a role in improving early-stage osseointegration. However, its effect on crestal bone level and bone density remains inconclusive. Preoperative vitamin D3 screening and supplementation in deficient individuals may optimize implant outcomes. Further large-scale studies are needed to establish definitive guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_649_25","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:46:14Z","timestamp":1761734774000},"page":"125-127","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Vitamin D3 Supplements in the Success of Dental Implants: A Comparative Evaluation"],"prefix":"10.4103","volume":"18","author":[{"given":"Nooka Surya","family":"Ramalakshmi","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gade Phani","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Samyuktha","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Batthula","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothirmai","family":"Nagisetty","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahnavi","family":"Valiveti","sequence":"additional","affiliation":[{"name":"Intern, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"R1-20260330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6639523","article-title":"The possible role of vitamin D deficiency in early implant failure","volume":"2021","author":"Hakim","year":"2021","journal-title":"Biomed Res Int"},{"key":"R2-20260330","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/njms.NJMS_49_20","article-title":"Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements","volume":"11","author":"Garg","year":"2020","journal-title":"Natl J Maxillofac Surg"},{"key":"R3-20260330","first-page":"1","article-title":"The role of vitamin D in dental implant osseointegration","volume":"4","author":"Vesala","year":"2020","journal-title":"J Frailty Sarcopenia Falls"},{"key":"R4-20260330","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/ID.0000000000000390","article-title":"Efficacy of vitamin D3 supplementation on osseointegration of implants","volume":"25","author":"Javed","year":"2016","journal-title":"Implant Dent"},{"key":"R5-20260330","doi-asserted-by":"crossref","first-page":"174","DOI":"10.15171\/joddd.2018.027","article-title":"Low serum vitamin D and early dental implant failure: Is there a connection? A retrospective clinical study on 1740 implants placed in 885 patients","volume":"12","author":"Guido Mangano","year":"2018","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"R6-20260330","doi-asserted-by":"crossref","first-page":"25","DOI":"10.29359\/BJHPA.10.4.02","article-title":"The effect of vitamin D3 on the osteointegration of dental implant","volume":"10","author":"Trybek","year":"2018","journal-title":"Balt J Health Phys Act"},{"key":"R7-20260330","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/jfmpc.jfmpc_78_18","article-title":"Vitamin D deficiency in India","volume":"7","author":"Aparna","year":"2018","journal-title":"J Family Med Prim Care"},{"key":"R8-20260330","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/nu16020209","article-title":"Impact of Vitamin D on Osseointegration in dental implants: A systematic review of human studies","volume":"16","author":"Buzatu","year":"2024","journal-title":"Nutrients"},{"key":"R9-20260330","first-page":"101","article-title":"Impact of vitamin D on osseointegration in smokers vs non-smokers","volume":"140","author":"Griffin","year":"2024","journal-title":"J Oral Implantol"},{"key":"R10-20260330","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/ard.2006.062018","article-title":"Genetic susceptibility to total hip arthroplasty failure: A preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor","volume":"66","author":"Malik","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"R11-20260330","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1600-0501.2011.02346.x","article-title":"Impact of dietary vitamin D on osseointegration in the ovariectomized rat","volume":"23","author":"Dvorak","year":"2012","journal-title":"Clin Oral Implants Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_649_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:26Z","timestamp":1787837066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_649_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_649_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-03-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}