{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:49Z","timestamp":1787762029677,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bioceramics are widely used as a biomaterial to promote bone regeneration. Bone defect management requires the placement of bone grafts. Though there are many bone grafts available, these have certain limitations like limited supply and second surgical site morbidity. Phytochemicals in plants are known to have bone regeneration capacity and are used in traditional medicine for bone fracture healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of the study was to create a novel biomaterial consisting of a composite of biphasic calcium phosphate (BCP), chitosan (CH), casein (CA), and ethanolic leaves extract of Ormocarpum Cochinchinense (OC) fabricated and characterized for physicochemical properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>BCP-CH-CA-OC material was prepared and immersed in Simulated body fluid (SBF) for 21 days. Physical properties were analysed through X-Ray diffraction (XRD), Fourier Transform Spectroscopy (FTIR), and Scanning Electron Microscopy with Energy dispersion spectroscopy (SEM\/EDS). Mechanical properties were analysed by compressive strength and diametral tensile strength tests. Using BET (Brunauer-Emmett-Teller) analysis and Nano computed tomography (CT) scan, porosity measurements were made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>XRD did not show any significant change after immersion in SBF, indicating that the material was not under change and is stable. FTIR showed an increase in chitosan content, due to the loss of casein. SEM analysis showed the deposition of crystals and porous structure. EDS showed the deposition of minerals. Nano CT and BET analysis showed clinically significant porosity of 30%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The mechanical and physical properties of this novel biomaterial could be used in tissue engineering for the repair of bone defects in non-load-bearing areas. The physicochemical properties are at par with other materials used for the purpose of bone grafting. The novel biomaterial has the potential to be used in bone regenerative medicine in non-load-bearing applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_678_22","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:07:24Z","timestamp":1689127644000},"page":"S608-S615","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Physicochemical Characterization of Novel Biomaterial Consisting of Biphasic Calcium Phosphate, Chitosan, Casein and Ethanolic Leaves Extract of Ormocarpum Cochinchinense"],"prefix":"10.4103","volume":"15","author":[{"given":"Gayathri","family":"Somashekar","sequence":"first","affiliation":[{"name":"Department of Periodontics, Dr. M.G.R Educational and Research Institute, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Sudhakar","sequence":"additional","affiliation":[{"name":"Department of Periodontics Thai Moogambigai Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PSG","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snophia","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Periodontics Thai Moogambigai Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Rajachandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Sathyabama Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Thirugnanasambandam","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Sathyabama Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Srividya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Sathyabama Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"488","DOI":"10.31788\/RJC.2018.1121916","article-title":"Fabrication of nanohydroxyapatite\/scrawl collagen\/chitosan composite for bone graft candidate","volume":"11","author":"Cahyaningrum","year":"2018","journal-title":"Rasayan J Chem"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"151762","DOI":"10.1016\/j.acthis.2021.151762","article-title":"Nile tilapia skin (Oreochromis niloticus) for burn treatment:Ultrastructural analysis and quantitative assessment of collagen","volume":"123","author":"Verde","year":"2021","journal-title":"Acta Histochem"},{"key":"R5-20240829","first-page":"571389","article-title":"Tilapia wastes to valuable materials:A brief review of biomedical, wastewater treatment, and biofuel applications","author":"Lee","year":"2022","journal-title":"Mater Today Proc"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1097\/SCS.0000000000004909","article-title":"Chitosan as a bone scaffold biomaterial","volume":"29","author":"Kozusko","year":"2018","journal-title":"J. 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