{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:16Z","timestamp":1787585956616,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6]]},"abstract":"\n Context:<\/jats:title>\n Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surgical therapy, and physiotherapy, has been attempted till date, with varying degrees of benefit.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The objective of this study was to assess efficacy of curcumin for the treatment of OSMF; to asses efficacy of topical steroids for the treatment of OSMF; and to compare the efficacy of curcumin and topical steroid for the treatment of OSMF.<\/jats:p>\n <\/jats:sec>\n \n Setting and Design:<\/jats:title>\n Participants were assessed based subjective and objective feature of OSMF, i.e., burning sensation of the oral cavity and interincisal distance, respectively.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Thirty participants were categorized into two groups: Group A was administered curcumin and Group B was administered topical steroids for a period of 3 months and followed up after 6 months. The assessment was based on maximal incisal opening and burning sensation for spicy food on Visual Analog Scale score.<\/jats:p>\n <\/jats:sec>\n \n Analysis:<\/jats:title>\n \n Independent t test was applied for comparison within the group, ANOVA Bonferroni\n post hoc<\/jats:italic>\n test was applied for multiple comparison of mean and Mann\u2013Whitney U test was applied to compare the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The statistical analysis revealed curcumin to be more efficient than topical steroid.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The present study demonstrates the efficiency of curcumin and topical steroid to alleviate the clinical findings of OSMF. However, curcumin is comparatively more efficient than steroids for the treatment of OSMF.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_687_20","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T07:46:24Z","timestamp":1622879184000},"page":"S542-S548","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study"],"prefix":"10.4103","volume":"13","author":[{"given":"T. A.","family":"Deepak","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, V S Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, V S Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshita","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, V S Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"key":"R1-20241204","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0714.1995.tb01209.x","article-title":"Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10 year experience with 150 cases","volume":"24","author":"Lai","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"R2-20241204","first-page":"17","article-title":"Oral submucous fibrosis: An unusual disease","volume":"68","author":"Aziz","year":"1997","journal-title":"J N J Dent Assoc"},{"key":"R3-20241204","first-page":"191","article-title":"Clinical and functional staging of OSMF","volume":"38","author":"Haider","year":"2000","journal-title":"B J of Oral Maxillofacial Surgery"},{"key":"R4-20241204","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/107555303321223035","article-title":"Safety and anti inflammatory activity of curcumin. A component of turmeric","volume":"9","author":"Chinani-Wu","year":"2003","journal-title":"J Altern Complement med"},{"key":"R5-20241204","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","article-title":"Nomenclature and classification of potentially malignant disorders of the oral mucosa","volume":"36","author":"Warnakulasuriya","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"R6-20241204","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1016\/j.oraloncology.2009.04.004","article-title":"Arecoline stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin","volume":"45","author":"Deng","year":"2009","journal-title":"Oral Oncol"},{"key":"R7-20241204","doi-asserted-by":"crossref","first-page":"423","DOI":"10.14219\/jada.archive.2010.0194","article-title":"Coming to America: Betel nut and oral submucous fibrosis","volume":"141","author":"Aziz","year":"2010","journal-title":"J Am Dent Assoc"},{"key":"R8-20241204","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/0972-1363.166922","article-title":"Comparative study of efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis a clinical and histopathological evaluation","volume":"22","author":"Das","year":"2010","journal-title":"J Indianacad Oral Med Radiol"},{"key":"R9-20241204","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jobcr.2013.10.005","article-title":"Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district","volume":"4","author":"Nigam","year":"2014","journal-title":"J Oral Biol Craniofacial Res"},{"key":"R10-20241204","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jobcr.2014.11.003","article-title":"Comparison of curcumin with intralesional steroid injections in oral submucous fibrosis \u2013 A randomized, open label interventional study","volume":"4","author":"Yadav","year":"2014","journal-title":"J Oral Biol Craniofac Res"},{"key":"R11-20241204","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/0973-029X.164524","article-title":"Efficacy of curcumin and turmeric agent as chemopreventive agents in oral submucous fibrosis","volume":"19","author":"Hazarey","year":"2015","journal-title":"J Oral Maxillofac Pathol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.JPBS_687_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:43:43Z","timestamp":1787067823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.JPBS_687_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":11,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_687_20","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-10-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}