{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:52:14Z","timestamp":1788465134792,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n \n Rosa rubiginosa<\/jats:italic>\n extracts were prepared, and the antibacterial and anti-biofilm assays were investigated against two different periodontics-causing bacteria for the first time. The aim was to determine whether the extracts could restrict the growth of dental pathogens and to investigate the molecular docking between the ellagic acid of flower extracts and virulence proteins of dental pathogens.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Method:<\/jats:title>\n \n Antibacterial activity of various extracts\n Rosa rubiginosa<\/jats:italic>\n was studied. Anti-adherence activity and molecular docking of the antibacterial components of the extract was analysed,\n <\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n \n The antibacterial activity of ethanol and methanol extracts of\n Rosa rubiginosa<\/jats:italic>\n was determined using the standard agar well diffusion method. Among them, methanol extracts showed more activity against all the dental pathogens. Methanol extracts (300 \u03bcg\/ml and 400 \u03bcg\/ml) showed inhibitory zones of 13.6 \u00b1 0.75 mm and 15.9 \u00b1 0.57 mm against\n Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans<\/jats:italic>\n showed inhibitory zones of about 12.9 \u00b1 0.57 mm and 16.6 \u00b1 0.75 mm. Minimum inhibitory concentration studies revealed that 500 \u03bcg\/ml of methanol extracts inhibited the turbid growth of\n Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans<\/jats:italic>\n in their broth tubes. Antiadherence test results showed that\n Rosa rubiginosa<\/jats:italic>\n extracts significantly reduced the number of organisms adhering to the glass specimens against all the test cultures. The molecular docking report revealed a binding energy of about -3.57 Kcal\/Mol between ellagic acid and mfa1 of\n Porphyromonas gingivalis<\/jats:italic>\n . Ellagic acid and target protein cdtA of\n Aggregatibacter actinomycetemcomitans<\/jats:italic>\n revealed a maximum binding energy of -4.33 Kcal\/Mol.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The findings concluded that\n Rosa rubiginosa<\/jats:italic>\n extracts can be a valuable additive in natural antidental biofilm products.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_697_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:01:58Z","timestamp":1738234918000},"page":"S4667-S4677","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Antibacterial Activity, Antiadherence Activity, Antioxidant Activity, and Molecular Docking of Sweetbrair Rose (Rosa Rubiginosa) Extract on Periodontopathogens: Porphyromonas Gingivalis and Aggregatibacter Actinomycetemcomitans \u2013 An In Vitro Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Syed Wali","family":"Peeran","sequence":"first","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hytham","family":"Fageeh","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Ibraheem","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammam I.","family":"Fageeh","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Al-Ak\u2019hali","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagabhushana","family":"Doggalli","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, JSS Dental College and Hospital, JHSS Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad N.","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Sciences, Division of Periodontics, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed N.","family":"Basheer","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of 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