{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:50:34Z","timestamp":1789156234519,"version":"build-2803163510"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Objectives:<\/jats:title>\n Comparative assessment of effectiveness of topical coconut cream, pomegranate, and Tacrolimus 0.1% in treatment of oral lichen planus (OLP) lesion.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Thirty patients with histologically confirmed symptomatic OLP exhibiting gingival manifestation were included in this investigation. Group A received topical coconut cream, Group B received pomegranate, and Group C received topical tacrolimus 0.1% ointment. The participants were split into these three groups. For six months, the participants were told to use topical medicines twice a day. For the purpose of monitoring any relapse, the patients were summoned back one, three, and six months after the therapy was stopped.<\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n Both the extent of the lesion and the burning sensation\/pain were significantly reduced in all groups of participants.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The size of the lesion and the burning feeling were significantly reduced when using coconut cream. For the treatment of OLP, tacrolimus, coconut cream, and pomegranates are viable topical pharmaceutical alternatives.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_709_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:04:04Z","timestamp":1735257844000},"page":"S3224-S3226","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Herbal Medicament in Treatment of Oral Lichen Planus Lesion"],"prefix":"10.4103","volume":"16","author":[{"given":"Ravinder","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, MMCDSR, Mullana, Ambala Cantt, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheena","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Maharshi Markandeswar College of Dental Sciences and Research, Mullana, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushruth","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Maharshi Markandeswar College of Dental Sciences and Research, Mullana, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Maharshi Markandeswar College of Dental Sciences and Research, Mullana, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veenu","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, MMCDSR, Mullana, Ambala Cantt, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Saidath","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, NITTE (Deemed to be University) AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1345\/aph.1M278","article-title":"Association between exposure to topical tacrolimus or pimecrolimus and cancers","volume":"43","author":"Hui","year":"2009","journal-title":"Ann Pharmacother"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/ijp.ijp_984_20","article-title":"Comparative efficacy of topical coconut cream and clobetasol propionate ointment for the management of oral lichen planus:A double-blinded randomized control trial","volume":"54","author":"Mamadapur","year":"2022","journal-title":"Indian J Pharmacol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0030-4220(68)90194-1","article-title":"Oral lichen planus. A clinical evaluation of 115 cases","volume":"25","author":"Andreasen","year":"1968","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21608\/adjc.2020.22381.1047","article-title":"Evaluation of topical pomegranate extracts in management of oral lichen planus:A randomized clinical trial","volume":"2","author":"Zakaria","year":"2020","journal-title":"Adv Dent J"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1079-2104(99)70033-8","article-title":"A review of the recent literature regarding malignant transformation of oral lichen planus","volume":"88","author":"van","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"42","DOI":"10.31782\/IJCRR.2021.13505","article-title":"Use of medicinal plants in oral lesions","volume":"13","author":"Sneha","year":"2021","journal-title":"Int J Cur Res Rev"},{"key":"R7-20241227","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4103\/0300-1652.153406","article-title":"Effect of coconut oil in plaque related gingivitis \u2013A preliminary report","volume":"56","author":"Peedikayil","year":"2015","journal-title":"Niger Med J"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2310\/6620.2008.08052","article-title":"Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis","volume":"19","author":"Verallo-Rowell","year":"2008","journal-title":"Dermatitis"},{"issue":"Suppl 1","key":"R9-20241227","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.4103\/jpbs.jpbs_416_23","article-title":"Efficacy of aloe vera, amlexanox (5%), and triamcinolone acetonide (0.1%) in the management of oral lichen planus","volume":"16","author":"Kaur","year":"2024","journal-title":"J Pharm Bioallied Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_709_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:43Z","timestamp":1786650043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_709_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_709_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"2024-06-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}