{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:20:31Z","timestamp":1787775631125,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset. The host immune system starts as an inflammatory process in response to microbial attack that protects and kills the periodontium. Doxycycline is a semi-synthetic variant of tetracycline that is made from oxytetracycline. Doxycycline inhibits the production of both aerobic and anaerobic microbial protein through its potent activity against both Gram-positive and Gram-negative bacteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The preparation method of doxycycline proniosomal gel involved accurately weighing doxycycline and all excipients (12 Batches). Doxycycline was mixed with 1 ml of ethanol, and all the excipients, like surfactant, lecithin, cholesterol, were added in precisely weighed amounts. The characterization of proniosomal gel and determination of drug entrapment efficacy is calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>Doxycycline release from the doxycycline proniosomal gel (Batch F12) was studied using Franz diffusion cell assembly with dialysis membrane for 7 days in phosphate-buffered saline (7.4) indicated sustained release of doxycycline from the formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Proniosome containing doxycycline may therefore be a locally effective drug delivery method for treating periodontitis. Current in vitro study is mainly focused on preparation of proniosomal gel containing doxycycline as local drug delivery system in periodontal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_726_24","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:29:18Z","timestamp":1725542958000},"page":"S3227-S3229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Dhawal Rajendra","family":"Mody","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Periodontology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrushali","family":"Lathiya","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Periodontology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay P.","family":"Kolte","sequence":"additional","affiliation":[{"name":"Dean, Professor and Head, Department of Periodontology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi","family":"Biradar","sequence":"additional","affiliation":[{"name":"Post Graduate Students, Department of Periodontology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi","family":"Langde","sequence":"additional","affiliation":[{"name":"Post Graduate Students, Department of Periodontology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5173(00)00669-4","article-title":"In-vitro skin permeation of estradiol from various proniosomes formulation","volume":"215","author":"Fang","year":"2001","journal-title":"Int J Pharm"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-5173(99)00122-2","article-title":"Proniosomes:A novel drug carrier preparation","volume":"185","author":"Hu","year":"1999","journal-title":"Int J Pharm"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/2231-4040.93558","article-title":"Intraperiodontal pocket:An ideal route for local antimicrobial drug 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