{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:21:45Z","timestamp":1787840505176,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Computer-aided design\/computer-aided manufacturing (CAD\/CAM) materials have revolutionized dental restorations, offering enhanced mechanical properties and esthetic outcomes. However, the fracture resistance of various CAD\/CAM materials used in fixed partial dentures (FPDs) remains a crucial determinant of their clinical success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Three CAD\/CAM materials\u2014lithium disilicate, zirconia, and resin-based composite\u2014were selected for the study. A total of 45 three-unit FPD frameworks (15 specimens for each material) were fabricated using standardized CAD\/CAM protocols. The frameworks were cemented onto artificial abutments and subjected to thermocycling to simulate oral conditions. Fracture resistance was tested using a universal testing machine, applying a load at a crosshead speed of 1 mm\/min until failure occurred. The fracture loads were recorded in Newtons (N) for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The zirconia group exhibited the highest mean fracture resistance (1,800 \u00b1 120 N), followed by lithium disilicate (1,200 \u00b1 100 N) and the resin-based composite (900 \u00b1 80 N). Statistical analysis using ANOVA revealed significant differences in fracture resistance among the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Failure modes varied, with zirconia specimens predominantly showing cohesive fractures, while lithium disilicate and the resin-based composite exhibited mixed failure patterns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Zirconia demonstrated superior fracture resistance compared to lithium disilicate and the resin-based composite, making it a more reliable material for FPDs in high-stress areas. Lithium disilicate remains a suitable option for esthetic regions, while the resin-based composite may be limited to low-stress applications. These findings underscore the importance of material selection based on clinical requirements to ensure long-term success of FPDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_72_25","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:03:19Z","timestamp":1750208599000},"page":"S1511-S1513","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Evaluation of the Fracture Resistance of CAD\/CAM Materials for Fixed Partial Dentures"],"prefix":"10.4103","volume":"17","author":[{"given":"Papala Sesha","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Government Dental College and Hospital, RIMS, Putlampalli, Kadapa, YSR (Dt.), Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallikarjun H.","family":"Doddamani","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Crown and Bridge, KAHER\u2019 Vishwanath Katti Institute of Dental Science, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngangbam Johnson","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dentistry, District Hospital, Harda, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashtha","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, SGT Dental College, Hospital and Research Institute, SGT University, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vijayakanth","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Anil Neerukonda Institute of Dental Sciences, Sangivalasa, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Veerakumar","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Vinayaka Mission\u2019s Sankarachariyar Dental College, Vinayaka Missions Research Foundation (Deemed to be University), Salem, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"R1-20250618","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.dental.2007.05.007","article-title":"State of the art of zirconia for dental applications","volume":"24","author":"Denry","year":"2008","journal-title":"Dent Mater"},{"key":"R2-20250618","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0142-9612(98)00010-6","article-title":"Zirconia as a ceramic biomaterial","volume":"20","author":"Piconi","year":"1999","journal-title":"Biomaterials"},{"issue":"(Suppl 1)","key":"R3-20250618","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1834-7819.2010.01299.x","article-title":"Ceramic materials in dentistry:Historical evolution and current practice","volume":"56","author":"Kelly","year":"2011","journal-title":"Aust Dent J"},{"key":"R4-20250618","doi-asserted-by":"crossref","first-page":"514","DOI":"10.14219\/jada.archive.2006.0224","article-title":"Fracture resistance of different partial coverage ceramic molar restorations:An in vitro investigation","volume":"137","author":"Stappert","year":"2006","journal-title":"J Am Dent Assoc"},{"key":"R5-20250618","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0022-3913(07)60124-3","article-title":"Current ceramic materials and systems with clinical recommendations:A systematic review","volume":"98","author":"Conrad","year":"2007","journal-title":"J Prosthet Dent"},{"key":"R6-20250618","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00016358609094346","article-title":"A clinical evaluation of anterior conventional, microfiller, and hybrid composite resin fillings:A 6-year follow-up study","volume":"44","author":"Van Dijken","year":"1986","journal-title":"Acta Odontol Scand"},{"key":"R7-20250618","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.dental.2010.10.020","article-title":"Resin composite\u2014state of the art","volume":"27","author":"Ferracane","year":"2011","journal-title":"Dent Mater"},{"key":"R8-20250618","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.dental.2008.08.009","article-title":"Approach for valuating the influence of laboratory simulation","volume":"25","author":"Rosentritt","year":"2009","journal-title":"Dent Mater"},{"key":"R9-20250618","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.dental.2015.02.011","article-title":"All-ceramic or metal-ceramic tooth-supported fixed dental prostheses (FDPs)?A systematic review of the survival and complication rates. Part I:Single crowns (SCs)","volume":"31","author":"Sailer","year":"2015","journal-title":"Dent Mater"},{"key":"R10-20250618","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0022034517737483","article-title":"Novel zirconia materials in dentistry","volume":"97","author":"Zhang","year":"2018","journal-title":"J Dent Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_72_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:04Z","timestamp":1787837044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_72_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":10,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_72_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-01-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}