{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:32:10Z","timestamp":1787841130751,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this article is to evaluate and compare the efficacy of subgingival application of ozonated olive oil, plain olive oil, and chlorhexidine gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>One hundred and twenty patients with chronic periodontitis were included in this study and assigned into three groups. In Group I, Group II, and Group III, SRP was done followed by subgingival application of ozonated olive oil, plain olive oil, and chlorhexidine gel in Group I, II, and III, respectively, at baseline 7, 14, and 21 days. Recordings of clinical parameters (gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL]) were done at baseline and one month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean GI, PPD, and CAL scores at baseline for Group I was 2.78 \u00b1 0.42, 2.78 \u00b1 0.42, and 2.66 \u00b1 0.38; for Group II was 2.64 \u00b1 0.39, 6.40 \u00b1 0.50, and 6.40 \u00b1 0.50; and for Group III was 6.00 \u00b1 0.00, 6.40 \u00b1 0.50, and 6.40 \u00b1 0.50, and the scores after one month for Group I was 1.10 \u00b1 0.38, 0.21 \u00b1 0.07, and 0.07 \u00b1 0.05; for Group II was 0.05 \u00b1 0.05, 5.40 \u00b1 0.50, and 5.75 \u00b1 0.44; and for Group III was 5.00 \u00b1 0.00, 5.75 \u00b1 0.44, and 5.28 \u00b1 0.45, with the level of significance being (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The ozonated olive oil and chlorhexidine gel have shown significant improvement in periodontal health compared to plain olive oil. Ozonated olive oil can be used as local drug delivery (LDD), an adjunct to SRP in chronic periodontitis which is safe and well accepted by patients without any noticeable side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_738_24","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:03:05Z","timestamp":1734001385000},"page":"S3332-S3334","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Olive Oil, Ozonated Olive Oil, and Chlorhexidine Gel as an Adjunct to Scaling and Root Planing in Chronic Periodontitis: A Clinical Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Koushik","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BJ Janardhana","family":"Amaranath","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anishka","family":"Dhanai","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Pallavi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Katiyar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1016\/S1532-3382(12)70013-1","article-title":"Local and systemic antimicrobial therapy in periodontics","volume":"12","author":"Herrera","year":"2012","journal-title":"J Evid Based Dent Pract"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.4103\/0976-9668.92318","article-title":"Ozone therapy in dentistry:A strategic review","volume":"2","author":"Saini","year":"2011","journal-title":"J Nat Sci Biol Med"},{"key":"R3-20241227","first-page":"7984","article-title":"Effect of Ozonised water on chronic periodontitis \u2013A clinical study","volume":"5","author":"Katti","year":"2013","journal-title":"J Int Oral Health"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1601-5037.2011.00506.x","article-title":"Management of gingival inflammation in orthodontic patients with ozonated water irrigation\u2013A pilot study","volume":"9","author":"Dhingra","year":"2011","journal-title":"Int J Dent Hyg"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"37988","DOI":"10.1007\/s00784-012-0711-7","article-title":"Clinical and microbiological effects of ozone nanobubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial","volume":"17","author":"Hayakumo","year":"2013","journal-title":"Clin 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trial","volume":"27","author":"Dengizek","year":"2019","journal-title":"J Appl Oral Sci"},{"key":"R9-20241227","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/odi.13060","article-title":"The effects of ozone therapy on periodontal therapy:A randomized placebo-controlled clinical trial","volume":"25","author":"Tasdemir","year":"2019","journal-title":"Oral Dis"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_738_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:43:00Z","timestamp":1787838180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_738_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_738_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-06-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}