{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:08Z","timestamp":1787070788090,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Opioid-free anesthesia (OFA) using multimodal analgesia and erector spinae plane block (ESPB) has shown promise in reducing opioid-related side effects in laparoscopic surgeries. We compared postoperative pain scores, intraoperative hemodynamics, analgesic requirements, and side effects between OFA with ESPB and opioid-based anesthesia (OBA).<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n Sixty patients undergoing elective laparoscopic surgery were randomized into two groups (\n n<\/jats:italic>\n = 30 each). Group A received OFA with lignocaine, magnesium sulfate, paracetamol, and bilateral ESPB. Group B received OBA with fentanyl. Pain scores (visual analog scale [VAS]), intraoperative heart rate, mean arterial pressure, analgesic consumption, and adverse events were recorded and analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n VAS scores were significantly lower in Group A at 1, 2, 3, 4, 16, and 24 h postoperatively (\n P<\/jats:italic>\n < 0.05). Group A showed greater hemodynamic stability and required significantly fewer rescue analgesics. Mean time to first analgesia was longer in Group A (12.93 \u00b1 3.81 h) versus Group B (1.70 \u00b1 0.92 h;\n P<\/jats:italic>\n = 0.001). Adverse events were more common in Group B but not statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n OFA with ESPB provides superior postoperative analgesia, better hemodynamic stability, and reduces opioid consumption and related side effects in laparoscopic surgeries.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_749_25","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T17:01:15Z","timestamp":1755190875000},"page":"S2804-S2806","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["To Compare Opioid Based versus Opioid-Free Anesthesia (Integrating with Erector Spinae Plane Block) in Laparoscopic Surgeries - A Prospective Study"],"prefix":"10.4103","volume":"17","author":[{"given":"Monika","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, M.G.M. Medical College and M.Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelapati","family":"Mouna","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, M.G.M. Medical College and M.Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, M.G.M. Medical College and M.Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Radiology, M.G.M. Medical College and M.Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Banjare","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, M.G.M. Medical College and M.Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1038\/s41598-018-27313-4","article-title":"Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist","volume":"8","author":"Spahn","year":"2018","journal-title":"Sci Rep"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/psychiatry.IndianJPsychiatry_385_18","article-title":"Research on opioid substitution therapy in India: A brief, narrative review","volume":"60","author":"Ambekar","year":"2018","journal-title":"Indian J Psychiatry"},{"key":"R3-20250930","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/ija.ija_785_21","article-title":"Opioid-free anaesthesia for laparoscopic surgeries-A prospective non- randomized study in a tertiary care hospital","volume":"66","author":"Ragupathy","year":"2022","journal-title":"Indian J Anaesth"},{"key":"R4-20250930","first-page":"256","article-title":"Opioid free anesthesia in laparoscopic surgery: A new emerging technique","volume":"8","author":"Kerketta","year":"2023","journal-title":"J Cell Mol Anesth"},{"key":"R5-20250930","first-page":"81","article-title":"Is opioid-free general anesthesia more superior for postoperative pain versus opioid general anesthesia in laparoscopic cholecystectomy?","volume":"40","author":"Toleska","year":"2019","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/AAP.0000000000000451","article-title":"The erector spinae plane block: A novel analgesic technique in thoracic neuropathic pain","volume":"41","author":"Forero","year":"2016","journal-title":"Reg Anesth Pain Med"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12630-020-01875-2","article-title":"Mechanisms of action of the erector spinae plane (ESP) block: A narrative review","volume":"68","author":"Chin","year":"2021","journal-title":"Can J Anaesth"},{"key":"R8-20250930","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/aer.AER_45_20","article-title":"Ultrasound- guided bilateral erector spinae plane block for postoperative analgesia in laparoscopic cholecystectomy: A randomized controlled trial","volume":"14","author":"Verma","year":"2020","journal-title":"Anesth Essays Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_749_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:36Z","timestamp":1787067396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_749_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":8,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_749_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"2025-03-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}