{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:15:01Z","timestamp":1790964901784,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Hepatocellular adenoma is a rare benign liver neoplasm, and hepatic adenomatosis is associated with risks such as intertumoral hemorrhage or necrosis. The imaging features of adenomatosis closely resemble those of solitary adenomas, differing only in the number of lesions. This study reports a case of an 18-year-old woman with perturbed liver function enzymes and multiple hepatic nodules. She had no significant medical history, chronic liver disease, or diabetes and was not taking any regular medications or anabolic steroids. Abdominal ultrasound revealed hepatomegaly and multiple hepatic nodules. Subsequently, the patient underwent hepatic orthotropic transplantation without any complications and was followed-up for 10 years. Multiple lesions with suspicious or confirmed malignant transformation and unwillingness to undergo surgical resection are considered leading indications for hepatic transplantation. Despite efforts to manage the condition conservatively, including hepatic transplantation, the patient experienced complications related to immunosuppressant therapy and ultimately developed chronic rejection. Hepatic transplantation is rarely indicated for benign liver tumors, especially when life-threatening complications or hepatic tumor malignant transformation cannot be ruled out, and tumors are unrespectable. This case highlights the complexity of managing hepatic adenomatosis and underscores the importance of individualized treatment strategies and long-term follow-up.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_754_24","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:10:10Z","timestamp":1726060210000},"page":"S4126-S4129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Long-term Outcomes (10 years) of Hepatic Transplantation in a Patient with Hepatic Adenomatosis: A Case Report"],"prefix":"10.4103","volume":"16","author":[{"given":"Abdullah","family":"Almunifi","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Majmaah University, Majmaah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"R1-20241227","first-page":"1345","article-title":"A case of hepatocellular adenomatosis with a follow-up of 11 years","volume":"90","author":"Propst","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1148\/radiographics.21.4.g01jl04877","article-title":"Hepatic adenomas:Imaging and pathologic findings","volume":"21","author":"Grazioli","year":"2001","journal-title":"RadioGraphics"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1111\/j.1399-3046.2008.01123.x","article-title":"The role of liver transplantation for hepatic adenomatosis in the pediatric population:Case report and review of the literature","volume":"14","author":"Wellen","year":"2010","journal-title":"Pediatr Transplant"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/0016-5085(85)90220-3","article-title":"Liver adenomatosis:An entity distinct from liver adenoma?","volume":"89","author":"Flejou","year":"1985","journal-title":"Gastroenterology"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1148\/radiology.216.2.r00jl38395","article-title":"Liver adenomatosis:Clinical, histopathological, and imaging findings in 15 patients","volume":"216","author":"Grazioli","year":"2000","journal-title":"Radiology"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng1001","article-title":"Bi-allelic inactivation of TCF1 in hepatic adenomas","volume":"32","author":"Bluteau","year":"2002","journal-title":"Nat Genet"},{"key":"R7-20241227","first-page":"1070","article-title":"Management issues regarding hepatic adenomatosis","volume":"65","author":"Yoshidome","year":"1999","journal-title":"Ann Med Surg"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/lt.500040505","article-title":"Management of liver adenomatosis:Results with a conservative surgical approach","volume":"4","author":"Ribeiro","year":"1998","journal-title":"Liver Transplant Surg"},{"key":"R9-20241227","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/1097-0142(19800301)45:5<1001::AID-CNCR2820450528>3.0.CO;2-F","article-title":"Multiple adenomas of the liver","volume":"45","author":"Lui","year":"1980","journal-title":"Cancer"},{"key":"R10-20241227","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF00206934","article-title":"Association of multiple liver cell adenomas with spontaneous intrahepatic portohepatic shunt","volume":"19","author":"Kawakatsu","year":"1994","journal-title":"Abdom Imaging"},{"key":"R11-20241227","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4065\/71.5.478","article-title":"Hepatic adenomatosis","volume":"71","author":"Arsenault","year":"1996","journal-title":"Mayo Clin Proc"},{"key":"R12-20241227","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00000658-200001000-00011","article-title":"Liver adenomatosis:Reappraisal, diagnosis, and surgical management:Eight new cases and review of the literature","volume":"231","author":"Chiche","year":"2000","journal-title":"Ann Surg"},{"key":"R13-20241227","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jamasurg.2014.3166","article-title":"Role of transplantation in the treatment of benign solid tumors of the liver:A review of the United Network of Organ Sharing data set","volume":"150","author":"Sundar Alagusundaramoorthy","year":"2015","journal-title":"JAMA Surg"},{"key":"R14-20241227","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11605-018-3917-4","article-title":"Approaches in the management of hepatic adenomas","volume":"23","author":"Tsilimigras","year":"2019","journal-title":"J Gastrointest Surg"},{"key":"R15-20241227","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00004836-200109000-00015","article-title":"Rapid disappearance of hepatic adenoma after contraceptive withdrawal","volume":"33","author":"Aseni","year":"2001","journal-title":"J Clin Gastroenterol"},{"key":"R16-20241227","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/00000658-198811000-00003","article-title":"Liver cell adenomas. A12-year surgical experience from a specialist hepato-biliary unit","volume":"208","author":"Leese","year":"1988","journal-title":"Ann Surg"},{"key":"R17-20241227","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s11605-020-04724-1","article-title":"Guidelines for the treatment of hepatocellular adenoma in the era of molecular biology:An experience-based surgeons'perspective","volume":"25","author":"Herman","year":"2021","journal-title":"J Gastrointest Surg"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_754_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:38:46Z","timestamp":1787773126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_754_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":17,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_754_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-06-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}