{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:26Z","timestamp":1787775986958,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ferritin plays a crucial role in the host immune response, with elevated serum ferritin levels established in various chronic inflammation-related diseases, including periodontitis. This study aimed to evaluate the efficacy of nonsurgical periodontal treatment on salivary ferritin levels in periodontally healthy and chronic periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifty patients were selected and divided into two groups a control group of healthy individuals and an experimental group of chronic periodontitis patients. Salivary samples were collected using the drooling method to assess ferritin levels. The experimental group underwent nonsurgical periodontal therapy, with clinical parameters [plaque index (PI), gingival index (GI), oral hygiene index-simplified (OHIS), bleeding point index (BPI), probing pocket depth (PPD), and clinical attachment level (CAL)] recorded before and one month after therapy. Salivary samples were analyzed using CLIA, and statistical analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The control group showed significantly lower ferritin levels compared to the periodontitis group. Post-therapy, the periodontitis group exhibited significant improvements in both clinical parameters and ferritin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Salivary ferritin levels effectively predict periodontal disease and the impact of periodontal therapy, demonstrating its potential as a valuable biomarker for diagnosing and monitoring periodontal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_759_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:03:46Z","timestamp":1735257826000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Salivary Ferritin Levels as a Predictor Inflammatory Biomarker Before and After Non Surgical Periodontal Therapy- An Interventional Study"],"prefix":"10.4103","author":[{"given":"Saurabh","family":"Tembhurne","sequence":"first","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin K.","family":"Malagi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis V.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitibhushan S.","family":"Pandaw","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arundhuti","family":"Mahato","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyal","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"R1-20250114","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: An introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol 2000"},{"key":"R3-20250114","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/0022034511399908","article-title":"Saliva\/pathogen biomarker signatures and periodontal disease progression","volume":"90","author":"Kinney","year":"2011","journal-title":"J Dent Res"},{"key":"R4-20250114","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1600-051X.2009.01480.x","article-title":"Salivary interleukin-1b concentration and the presence of multiple pathogens in periodontitis","volume":"36","author":"Gursoy","year":"2009","journal-title":"J Clin Periodontol"},{"key":"R5-20250114","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1550-7408.1999.tb05119.x","article-title":"The role of iron in protozoan and fungal infectious diseases","volume":"46","author":"Weinberg","year":"1999","journal-title":"J Eukaryot Microbiol"},{"key":"R6-20250114","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"R7-20250114","first-page":"594","article-title":"Serum ferritin level and its relation with chronic periodontitis \u2013 A clinical study","volume":"18","author":"Chakraborty","year":"2014","journal-title":"J Indian Soc Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_759_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:47:28Z","timestamp":1787773648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_759_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":6,"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_759_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"2024-07-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}