{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:57:10Z","timestamp":1792612630719,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      A denture wearer is highly prone to develop\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      -associated denture stomatitis (CADS) due to the conversion of the normal oral commensal\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      spp. into a pathogen under favorable conditions. Immuno-compromised status, trauma from the prosthesis, other systemic conditions, and improper maintenance of the dentures by the patient are few of the causative agents which turn the oral balance into an unhealthy and unsuitable foundation for the wearing of the prosthesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to compare subjects wearing complete dentures and nondenture wearers regarding\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates associated with disease and colonization among the different age groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among 60 subjects, 30 wearing complete dentures (Group-A) and 30 nondentures wearers (Group-B), were matched for gender, race, and age. The unstimulated saliva sample was collected and cultured in CHROMagar using standard protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean value of the candidal colony-forming units with respect to Group A is\n                      <jats:italic toggle=\"yes\">Candida Albicans<\/jats:italic>\n                      0.36 \u00b1 2.008,\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      krusei 0.27 \u00b1 1.061,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value Group B:\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      0.73 \u00b1 2.196,\n                      <jats:italic toggle=\"yes\">C. krusei<\/jats:italic>\n                      0.36 \u00b1 1.084. There was a significant relation between denture wearers and heavy growth of\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">C. krusei<\/jats:italic>\n                      in saliva culture with a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of P-0.054 and P-0.036, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These results indicate that denture wearers with oral\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      had a higher prevalence of CADS. Patients with removable prostheses should be informed about the importance of proper prosthesis and personal hygiene since dentures and age-related immunosuppression are both well-known risk factors associated with candidiasis development, the presence of yeast, even in healthy denture wearers, should be considered a risk factor for denture stomatitis that increases with the duration of denture use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_781_21","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:05:34Z","timestamp":1657724734000},"page":"S702-S705","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["Prevalence of Candida among Denture Wearers and Nondenture Wearers"],"prefix":"10.4103","volume":"14","author":[{"given":"Saranya","family":"Manikandan","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Vivekanandha Dental College for Women, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vinesh","sequence":"additional","affiliation":[{"name":"Dental Wing Panimalar Medical College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Thamarai","family":"Selvi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Rajah Muthiah Dental College and Hospital, Chidambaram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Kamala","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Karpaga Vinayaga Institute of Dental Sciences, Kanchipuram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Karpaga Vinayaga Institute of Dental Sciences, Kanchipuram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dinakaran","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Adhiparasakthi Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0109-5641(03)00088-5","article-title":"Colonization and penetration of denture soft lining materials by Candida albicans","volume":"20","author":"Bulad","year":"2004","journal-title":"Dent Mater"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1177\/00220345950740050301","article-title":"Oral candida: Clearance, colonization, or candidiasis?","volume":"74","author":"Cannon","year":"1995","journal-title":"J Dent Res"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tripleo.2003.10.006","article-title":"Evaluation of the recurrence of denture stomatitis and candida colonization in a small group of patients who received itraconazole","volume":"97","author":"Cross","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R4-20250925","first-page":"36","article-title":"Oral candidiasis: A review","volume":"2","author":"Dangi","year":"2010","journal-title":"Int J Pharm Pharm Sci"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1399-302X.2009.00505.x","article-title":"Oral candida infection and colonization in solid organ transplant recipients","volume":"24","author":"Dongari-Bagtzoglou","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1600-0714.2007.00572.x","article-title":"Oral manifestation of chronic mucocutaneous candidiasis: Seven case reports","volume":"36","author":"Liu","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"R7-20250925","first-page":"55","article-title":"Candida-related denture stomatitis: A pilot study of the efficacy of an amorolfine antifungal varnish","volume":"18","author":"Milillo","year":"2005","journal-title":"Int J Prosthodont"},{"key":"R8-20250925","first-page":"189","article-title":"Oral candidiasis in immunosuppressed children and young adults after liver or kidney transplantation","volume":"32","author":"Olczak-Kowalczyk","year":"2010","journal-title":"Pediatr Dent"},{"key":"R9-20250925","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1590\/S1678-77572008000200002","article-title":"Development of Candida-associated denture stomatitis: New insights","volume":"16","author":"Pereira-Cenci","year":"2008","journal-title":"J Appl Oral Sci"},{"key":"R10-20250925","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.prosdent.2004.11.015","article-title":"Colonization of candida species in denture wearers with emphasis on HIV infection: A literature review","volume":"93","author":"Perezous","year":"2005","journal-title":"J Prosthet Dent"},{"key":"R11-20250925","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1600-0714.2007.00535.x","article-title":"Prevalence of oral candida species in leprosy patients from Cambodia and Thailand","volume":"36","author":"Reichart","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"R12-20250925","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.4317\/medoral.16.e139","article-title":"Candida-associated denture stomatitis","volume":"16","author":"Salerno","year":"2011","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R13-20250925","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411940050020101","article-title":"Candida and oral candidosis: A review","volume":"5","author":"Scully","year":"1994","journal-title":"Crit Rev Oral Biol Med"},{"key":"R14-20250925","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.tripleo.2009.11.026","article-title":"Oropharyngeal candidiasis in the era of antiretroviral therapy","volume":"109","author":"Thompson","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R15-20250925","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1834-7819.1998.tb00172.x","article-title":"Candida-associated denture stomatitis. Aetiology and management: A review. Part 3. Treatment of oral candidosis","volume":"43","author":"Webb","year":"1998","journal-title":"Aust Dent J"},{"key":"R16-20250925","first-page":"31","article-title":"Oral candidiasis: Diagnosis and treatment","volume":"26","author":"Zunt","year":"2000","journal-title":"J Pract Hyg"},{"key":"R17-20250925","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tripleo.2003.04.002","article-title":"Denture stomatitis: A role for candida biofilms","volume":"98","author":"Ramage","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R18-20250925","first-page":"113","article-title":"The association of denture stomatitis and partial removable dental prostheses: A systematic review","volume":"25","author":"Emami","year":"2012","journal-title":"Int J Prosthodont"},{"key":"R19-20250925","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tripleo.2011.02.033","article-title":"Candida spp. prevalence in well controlled type 2 diabetic patients with denture stomatitis","volume":"111","author":"Sanit\u00e1","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R20-20250925","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0714.2010.00981.x","article-title":"Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium","volume":"40","author":"Silva","year":"2011","journal-title":"J Oral Pathol Med"},{"issue":"Suppl 1","key":"R21-20250925","doi-asserted-by":"crossref","first-page":"i5","DOI":"10.1093\/jac\/dki218","article-title":"Changing patterns and trends in systemic fungal infections","volume":"56","author":"Richardson","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"R22-20250925","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3201\/eid1001.030119","article-title":"Fungal biofilms and drug resistance","volume":"10","author":"Jabra-Rizk","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"R23-20250925","first-page":"5","article-title":"Use of CHROMagar candida for the presumptive identification of candida species directly from clinical specimens in resource-limited settings","author":"Nadeem","year":"2010","journal-title":"Libyan J Med"},{"key":"R24-20250925","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-0711-2-8","article-title":"Performance of CHROMAGAR candida and BIGGY agar for identification of yeast species","volume":"2","author":"Y\u00fccesoy","year":"2003","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"R25-20250925","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v3i0.5771","article-title":"Pathogenesis and treatment of oral candidosis","volume":"3","author":"Williams","year":"2011","journal-title":"J Oral Microbiol"},{"key":"R26-20250925","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-0714.2009.00866.x","article-title":"Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata","volume":"39","author":"P\u00e4rn\u00e4nen","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"R27-20250925","first-page":"127","article-title":"Candida albicans isolation from buccal mucosa of patients with HIV wearing removable dental prostheses","volume":"25","author":"Witzel","year":"2012","journal-title":"Int J Prosthodont"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_781_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:34:56Z","timestamp":1787067296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_781_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":27,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_781_21","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2021-12-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}