{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:29Z","timestamp":1786653689615,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Surgical site infections (SSIs) are a serious concern in cesarean sections, leading to research on improved preventive measures, to evaluate the effectiveness of standard antibiotic prophylaxis alone versus an extended regimen that includes azithromycin in reducing SSIs in nonelective cesarean sections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this randomized controlled trial, 288 women who were undergoing nonelective cesarean sections at a tertiary care hospital in South India were involved. Participants were divided into two groups: one receiving standard prophylaxis with cefazolin and the other receiving an extended regimen with azithromycin. The main focus was on the occurrence of SSIs within six weeks after the surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The extended regimen group had a slightly lower incidence of SSIs (1.42%) compared to the standard regimen group (6.12%), but this difference did not reach statistical significance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.112).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the inclusion of azithromycin alongside standard prophylactic antibiotics demonstrated a slight decrease in SSIs, the results did not reach statistical significance. These findings indicate potential advantages in certain patient groups, which should be explored in more detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_783_24","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:06:55Z","timestamp":1735258015000},"page":"S3370-S3373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections"],"prefix":"10.4103","volume":"16","author":[{"given":"Sumangali","family":"Thirunavukkarausu","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynaecology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima","family":"Chinnappa","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupriya","family":"Kaliamoorthi","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMoa1602044","article-title":"Adjunctive azithromycin prophylaxis for cesarean delivery","volume":"375","author":"Tita","year":"2016","journal-title":"N Engl J Med"},{"key":"R2-20241227","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.4103\/jfmpc.jfmpc_593_19","article-title":"Randomized controlled trial of cefazolin monotherapy versus cefazolin plus azithromycin single dose prophylaxis for cesarean deliveries:A developing country's perspective","volume":"8","author":"Jyothi","year":"2019","journal-title":"J Fam Med Prim Care"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1186\/s12879-019-4383-7","article-title":"Surgical site infections after cesarean sections at the University Clinical Center of Kosovo:Rates, microbiological profile and risk factors","volume":"19","author":"Zejnullahu","year":"2019","journal-title":"BMC Infect Dis"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1097\/AOG.0000000000002333","article-title":"Adding azithromycin to cephalosporin for cesarean delivery infection prophylaxis:A cost-effectiveness analysis","volume":"130","author":"Skeith","year":"2017","journal-title":"Obstet Gynecol"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMoa1602044","article-title":"Adjunctive azithromycin prophylaxis for cesarean delivery","volume":"375","author":"Tita","year":"2016","journal-title":"N Engl J Med"},{"key":"R6-20241227","article-title":"ACOG Practice Bulletin No. 199:Use of prophylactic antibiotics in labor and delivery","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"key":"R7-20241227","doi-asserted-by":"crossref","first-page":"566","DOI":"10.15252\/embr.201540398","article-title":"The ethics of global clinical trials:In developing countries, participation in clinical trials is sometimes the only way to access medical treatment. What should be done to avoid exploitation of disadvantaged populations?","volume":"16","author":"Weigmann","year":"2015","journal-title":"EMBO Rep"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1111\/aogs.14235","article-title":"Risk factors for surgical site infection following cesarean delivery:A hospital-based case\u2013control study","volume":"100","author":"Kvalvik","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R9-20241227","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1080\/14767058.2017.1330882","article-title":"Surgical site infection after cesarean delivery:incidence and risk factors at a US academic institution","volume":"31","author":"Moulton","year":"2017","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_783_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:00Z","timestamp":1786650060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_783_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_783_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-07-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}