{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:11Z","timestamp":1787840531282,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      This study introduces a novel fast-setting\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      gel formulation enriched with vitamin D3 for alveolar bone regeneration. Using poloxamer-P407 (pluronic-f127) as the gel base, this innovative biomaterial aims to improve the efficacy and handling of bone grafts in periodontal and peri-implant regenerative therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The vitamin D3 formulation was prepared using cold method for\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      gel preparation with aseptic processing and sterilization by autoclaving. After this, the physicochemical properties, antimicrobial effect, and\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      drug release profile of the gel were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The gel demonstrated favorable clarity, almost neutral pH (6.11), thermoreversible gelation, stable at room temperature, viscosity 32500 cps, good spreadability 2.75 gm.cm\/sec, drug release 82.86% after 20 h and antimicrobial activity, making it a promising candidate for clinical applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The vitamin D3\u2013enriched Poloxamer-P407\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      gel demonstrated excellent physicochemical stability, favorable drug release, antimicrobial properties, and strong compatibility, forming a uniform, mechanically robust gel. These attributes make it a promising adjunct for enhancing bone graft efficacy in periodontal and peri-implant therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_801_25","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:00:08Z","timestamp":1754982008000},"page":"S2748-S2750","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Formulation and Characterization of Vitamin D3 In Situ Gel for Periodontal Regenerative Therapy"],"prefix":"10.4103","volume":"17","author":[{"given":"Pranjali V.","family":"Bawankar","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implantology, VSPM\u2019s Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Affiliated to MUHS Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay P","family":"Kolte","sequence":"additional","affiliation":[{"name":"Dean, VSPM's Ranjeet Deshmukh Dental College and Research Centre, Nagpur Affiliated to MUHS Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, VSPM\u2019s Ranjeet Deshmukh Dental College and Research Centre, Nagpur, Affiliated to MUHS Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.3390\/ijerph19074147","article-title":"Incidence of peri-implantitis and relationship with different conditions: A retrospective study","volume":"19","author":"Astolfi","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","article-title":"Bone grafts in dental medicine: An overview of autografts, allografts and synthetic materials","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials (Basel)"},{"key":"R3-20250930","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4248\/BR201303002","article-title":"Bone regeneration based on tissue engineering conceptions - A 21st century perspective","volume":"1","author":"Henkel","year":"2013","journal-title":"Bone Res"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"rbac098","DOI":"10.1093\/rb\/rbac098","article-title":"Recent advances in regenerative biomaterials","volume":"9","author":"Cao","year":"2022","journal-title":"Regen Biomater"},{"key":"R5-20250930","first-page":"3","article-title":"Success rate of dental implants inserted in autologous bone graft regenerated areas: A systematic review","volume":"4","author":"Clementini","year":"2011","journal-title":"Oral Implantol (Rome)"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/eos.12364","article-title":"Guided bone regeneration: Materials and biological mechanisms revisited","volume":"125","author":"Elgali","year":"2017","journal-title":"Eur J Oral Sci"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/pathogens12091180","article-title":"Influence of Vitamin D on Periodontal Inflammation: A Review","volume":"12","author":"Meghil","year":"2023","journal-title":"Pathogens"},{"key":"R8-20250930","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/0022034513495239","article-title":"Vitamin D and periodontal health in older men","volume":"92","author":"Alshouibi","year":"2013","journal-title":"J Dent Res"},{"key":"R9-20250930","first-page":"5869676","article-title":"Effect of supplementation of vitamin D in patients with periodontitis evaluated before and after nonsurgical therapy","author":"Mishra","year":"2022","journal-title":"Biomed Res Int 2022"},{"key":"R10-20250930","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/pharmaceutics15041312","article-title":"Local Delivery and Controlled Release Drugs Systems: A New Approach for the Clinical Treatment of Periodontitis Therapy","volume":"15","author":"Amato","year":"2023","journal-title":"Pharmaceutics"},{"key":"R11-20250930","doi-asserted-by":"crossref","first-page":"e00390","DOI":"10.1016\/j.heliyon.2017.e00390","article-title":"Thermogelling properties of purified poloxamer 407","volume":"3","author":"Fakhari","year":"2017","journal-title":"Heliyon"},{"key":"R12-20250930","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm Res"},{"key":"R13-20250930","doi-asserted-by":"crossref","first-page":"1900809","DOI":"10.1002\/mame.201900809","article-title":"Synthesis of glutamic acid-derived organogels and their applications in dye removal from aqueous medium","volume":"305","author":"Sar","year":"2020","journal-title":"Macromol Mater Eng"},{"key":"R14-20250930","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1021\/acsapm.0c00204","article-title":"Self-assembly of amphiphilic copolymers with sequence-controlled alternating hydrophilic\u2013hydrophobic pendant side chains","volume":"2","author":"Goswami","year":"2020","journal-title":"ACS Appl Polym Mater"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_801_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:34Z","timestamp":1787837074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_801_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":14,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_801_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"2025-04-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}