{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:10Z","timestamp":1787071150361,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Background:<\/jats:title>\n Sinonasal squamous cell carcinomas (SCCs) present a great challenge in their diagnosis and management owing to their rapid growth, regional recurrence, local recurrence, and aggressive spread locally.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The present clinical trial was conducted to evaluate anatomic subsites' impact on the outcomes concerning SCCs affecting ethmoid sinuses and nasal cavity.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Medical records for tumor staging, tumor classification, grading (histologic) clinical features, symptoms, anatomic subsite, p16 results, treatment provided, and the Tumor-related outcomes were obtained for 28 subjects. Following staging and grading, p16 assays were evaluated along with disease-specific survival and disease-free survival. The collected data were subjected to the statistical evaluation and the results were formulated by keeping the level of significance at\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Origin was seen from nasal septum, nasal floor, lateral wall, ethmoid sinus, and edge of naris to mucocutaneous junction in 21.4% (\n n<\/jats:italic>\n = 6), 7.14% (\n n<\/jats:italic>\n = 2), 35.71% (\n n<\/jats:italic>\n = 10), 7.14% (\n n<\/jats:italic>\n = 2), and 28.57% (\n n<\/jats:italic>\n = 8) subjects, respectively. For tumor staging, Stages I, II, III, and IV tumors were seen in, respectively, 39.28% (\n n<\/jats:italic>\n = 11), 21.42% (\n n<\/jats:italic>\n = 6), 10.71% (\n n<\/jats:italic>\n = 3), and 28.57% (\n n<\/jats:italic>\n = 8) study subjects. Node status was N0, N1, N2, and N3 in 78.57% (\n n<\/jats:italic>\n = 22), 3.57% (\n n<\/jats:italic>\n = 1), 7.14% (\n n<\/jats:italic>\n = 2), and 10.71% (\n n<\/jats:italic>\n = 3) subjects. Carcinoma arising from nasal septum had statistically significant worse disease-specific survival compared to carcinomas arising from other sites (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The present study concludes that anatomic subsites largely govern the outcomes and tumor behavior. Also, squamous cell carcinoma affecting the nasal septum is an aggressive tumor with more compromised outcomes and more lymph node involvement.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_811_21","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:05:34Z","timestamp":1657724734000},"page":"S1004-S1008","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Assessment of Anatomic Origin Effect on the Clinical Outcomes in Primary Squamous Cell Carcinomas Affecting Nasoethmoidal Complex"],"prefix":"10.4103","volume":"14","author":[{"given":"Bheemappa F","family":"Bangeennavar","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Reader, P. M. Nadgowda Memorial Dental College and Hospital, Bagalkote, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagisha","family":"Barbi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Senior Resident, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Nayan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Crown And Bridge, Reader, Mthila Minority Dental College And Hospital, Darbhanga, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalima","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacal Orthopedics, Lecturer, Patna Dental College and Hospital, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kundirthi Chaitanya","family":"Babjee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Assistant Professor, ESIC Medical College and PGIMSR, Chennai, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Sonali","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, PG Student, Hazaribagh College of Dental Sciences and Hospital, Hazaribagh, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4103\/jomfp.JOMFP_300_18","article-title":"Diagnostic challenges in malignant tumors of the nasal cavity and paranasal sinuses","volume":"23","author":"Devi","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"R2-20250925","first-page":"4508","article-title":"An aggressive case of sinonasal squamous cell carcinoma, invasive to bone, arising within inverted papilloma with intracranial extension: A case report","volume":"11","author":"De Jesus","year":"2019","journal-title":"Cureus"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/archotol.133.2.131","article-title":"Survival rates of sinonasal squamous cell carcinoma with the new AJCC staging system","volume":"133","author":"Lee","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/lary.26272","article-title":"Oncologic outcomes of selective neck dissection in HPV-related oropharyngeal squamous cell carcinoma","volume":"127","author":"Zenga","year":"2017","journal-title":"Laryngoscope"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/jcm6120116","article-title":"Imaging characteristics of malignant sinonasal tumors?","volume":"6","author":"Kawaguchi","year":"2017","journal-title":"J Clin Med"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1080\/0284186X.2016.1216656","article-title":"Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: A SEER analysis","volume":"55","author":"Ahn","year":"2016","journal-title":"Acta Oncol"},{"key":"R7-20250925","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijrobp.2007.10.031","article-title":"Long-term radiotherapy outcomes for nasal cavity and septal cancers","volume":"71","author":"Allen","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R8-20250925","first-page":"560","article-title":"Squamous cell carcinoma of the nasal cavity: A population-based analysis. Laryngoscope","volume":"126","author":"Unsal","year":"2016"},{"key":"R9-20250925","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/archotol.133.8.796","article-title":"Regional recurrence of squamous cell carcinoma of the nasal cavity. A systematic review and meta-analysis","volume":"133","author":"Scurry","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R10-20250925","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"R11-20250925","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/lary.26477","article-title":"Outcomes of HPV-related nasal squamous cell carcinoma","volume":"127","author":"Chowdhury","year":"2017","journal-title":"Laryngoscope"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_811_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:14Z","timestamp":1787067734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_811_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":11,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_811_21","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2021-12-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}