{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:19Z","timestamp":1787071639681,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Introduction:<\/jats:title>\n Dengue fever is a significant public health issue, affecting nearly 100 million people globally each year.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This study investigates dengue infection trends, particularly focusing on thrombocytopenia and neurological symptoms in confirmed cases.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A total of 1,558 blood samples were collected from probable dengue patients. Serological tests for NS1 antigen detection and IgM\/IgG antibody titers were performed using enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In total, 166 samples (10.65%) out of 1,558 tested positive for dengue. IgM showed the highest positivity (40.47%), followed by NS1 antigen (37.5%). Males were more frequently affected than females, with a male-to-female ratio of 1.8:1. The age group of 21\u201330 years accounted for the largest number of cases (32.14%). Thrombocytopenia was observed in 88.09% of dengue-positive cases, with 26.19% having platelet counts below 50,000 cells\/cumm. A few pediatric patients displayed severe neurological complications, including encephalitis, meningitis, and encephalopathy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This study highlights the importance of using IgG\/IgM ratios to differentiate primary from secondary dengue infections; in addition, to control the severity of the disease, regular thrombocyte measurement is required and is highly recommended.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_841_25","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:00:07Z","timestamp":1754035207000},"page":"S2776-S2778","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Dengue Surveillance in Remote Tribal Communities of Chhattisgarh through Integrated Serological Diagnostics: An Observational Approach"],"prefix":"10.4103","volume":"17","author":[{"given":"Rani","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Applied Science, Shri Rawatpura Sarkar University, Raipur, Chhattisgarh, India"},{"name":"Department of Microbiology, Lt Baliram Kashyap Memorial Govt. Medical College Jagdalpur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Applied Science, Shri Rawatpura Sarkar University, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashish","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Lt Baliram Kashyap Memorial Govt. Medical College Jagdalpur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahina","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Lt Baliram Kashyap Memorial Govt. Medical College Jagdalpur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishriram","family":"Rathored","sequence":"additional","affiliation":[{"name":"Central Research Laboratory and Molecular Diagnostics, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"R1-20250930","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7861\/clinmed.2021-0791","article-title":"Dengue infection: Global importance, immunopathology and management","volume":"22","author":"Kularatne","year":"2022","journal-title":"Clin Med"},{"key":"R2-20250930","doi-asserted-by":"crossref","first-page":"104723","DOI":"10.1016\/j.ebiom.2023.104723","article-title":"Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks","volume":"94","author":"Li","year":"2023","journal-title":"eBioMedicine"},{"key":"R3-20250930","first-page":"4224816","article-title":"Production, transmission, pathogenesis, and control of dengue virus: A literature-based undivided perspective","author":"Islam","year":"2021","journal-title":"BioMed Res Int 2021"},{"key":"R4-20250930","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s40572-018-0199-7","article-title":"Climate change impacts on waterborne diseases: Moving toward designing interventions","volume":"5","author":"Levy","year":"2018","journal-title":"Curr Environ Health Rep"},{"key":"R5-20250930","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3389\/fcimb.2017.00449","article-title":"Neurological manifestations of dengue infection","volume":"7","author":"Li","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"R6-20250930","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11910-022-01213-7","article-title":"Neurological complications of dengue fever","volume":"22","author":"Trivedi","year":"2022","journal-title":"Curr Neurol Neurosci Rep"},{"key":"R7-20250930","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cll.2009.10.007","article-title":"Dengue virus","volume":"30","author":"Ross","year":"2010","journal-title":"Clin Lab Med"},{"key":"R9-20250930","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: An integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"R10-20250930","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/bios11070206","article-title":"Dengue detection: advances in diagnostic tools from conventional technology to point of care","volume":"11","author":"Kabir","year":"2021","journal-title":"Biosensors (Basel)"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_841_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:08Z","timestamp":1787068208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_841_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":9,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_841_25","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-04-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}