{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:15Z","timestamp":1787071455986,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>OSCC stands as a prominent oral malignancy that develops because of lifestyle behavior and microbial activity. The pathogenesis of OSCC receives attention through modern research since Candida species reportedly contribute to the development of OSCC through inflammatory responses and nitrosamine generation and epithelial tissue malformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Sixty subjects participated in this\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      study, which was separated into two distinct groups: Group A with 30 patients who had high OSCC risk oral lesions (leukoplakia and erythroplakia) and Group B which included 30 healthy subjects. A laboratory research involved collecting samples through swabs from saliva and mucosa, which were subsequently cultured on Sabouraud Dextrose Agar (SDA) alongside CHROMagar for fungal detection. The researchers identified isolated colonies by checking their ability to form germ tubes combined with carbohydrate assimilation tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of the 30 Group A samples, 80% (24\/30) demonstrated candidal growth where Candida albicans constituted 70.8% of strains and Candida tropicalis made up 16.7% alongside Candida glabrata counting for 12.5%. The overall candidal growth among participants in Group B was limited to 30% (9\/30) as C. albicans constituted 88.9%, whereas C. glabrata accounted for 11.1%. The incidence of candidal colonization proved markedly higher among the high-risk group compared to controls according to statistical analysis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The numbers of Candida species, particularly C. albicans, rise substantially within the oral environments of patients dealing with potentially malignant disorders. The obtained data support the possibility that oral cancer development may be related to candidal colonization, thus demanding additional studies on this association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_894_25","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:00:09Z","timestamp":1766044809000},"page":"S2870-S2872","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An In vitro Study of the Isolation of Candidal Strains in Patients at Increased Risk of Oral Squamous Cell Carcinoma"],"prefix":"10.4103","volume":"17","author":[{"given":"Ruchi","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Microbiology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virag","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Government Medical College, Haldwani, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantala R.","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dental Institute, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, SMBT Institute of Dental Sciences and Research, Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Dwivedy","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, SMBT Institute of Dental Science and Research, Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhumika J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Howard University, College of Dentistry, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanpal Singh","family":"Makkad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology New Horizon Dental College and Research Institute, Bilaspur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"R1-20251218","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0973-029X.203793","article-title":"An in vitro study of isolation of candidal strains in oral squamous cell carcinoma patients undergoing radiation therapy and quantitative analysis of the various strains using CHROMagar","volume":"21","author":"Ainapur","year":"2017","journal-title":"J Oral Maxillofac Pathol"},{"issue":"Suppl 2","key":"R2-20251218","doi-asserted-by":"crossref","first-page":"S1050","DOI":"10.4103\/jpbs.jpbs_357_21","article-title":"Investigation of Candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma","volume":"13","author":"Abidullah","year":"2021","journal-title":"J Pharm Bioallied Sci"},{"key":"R3-20251218","first-page":"e657","article-title":"Speciation of Candida using CHROMagar in cases with oral epithelial dysplasia and squamous cell carcinoma","volume":"10","author":"Hulimane","year":"2018","journal-title":"J Clin Exp Dent"},{"key":"R4-20251218","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/jomfp.JOMFP_111_18","article-title":"Evaluation of candidal species among individuals with oral potentially malignant disorders and oral squamous cell carcinoma","volume":"23","author":"Roy","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"issue":"19","key":"R5-20251218","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.6026\/973206300191371","article-title":"Management of zygomatic fractures using different surgical approaches","volume":"31","author":"Mishra","year":"2023","journal-title":"Bioinformation"},{"key":"R6-20251218","first-page":"156","article-title":"An assessment of candidal colonization and species differentiation in head and neck cancer patients receiving radiation","volume":"12","author":"Shrestha","year":"2014","journal-title":"J Nepal Health Res Counc"},{"key":"R7-20251218","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1079-2104(97)90061-5","article-title":"Candidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapy","volume":"84","author":"Ramirez-Amador","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20251218","first-page":"15","article-title":"Candidal carriage in diabetic patients: A microbiological study","volume":"13","author":"Soni","year":"2019","journal-title":"J Exp Ther Oncol"},{"issue":"Suppl 1","key":"R9-20251218","doi-asserted-by":"crossref","first-page":"S820","DOI":"10.4103\/jpbs.jpbs_9_22","article-title":"Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Retrospective 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