{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:27:51Z","timestamp":1787840871653,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Evaluation of effectiveness of bioactive glass, self-assembling peptide (P11-4), and arginine bicarbonate remineralizing agents on simulated carious lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This research was conducted using 40 human premolar teeth that had just been removed. Remineralization of demineralized teeth was carried out three times a day for 14 days for 5 minutes using the appropriate remineralizing agents (Group A: calcium sodium phosphosilicate (bioactive glass), Group B: self-assembling peptide (P11-4), Group C: arginine bicarbonate remineralizing agents, and control group: Group D: deionized water). Using the Vickers hardness number, the degree of demineralization and remineralization was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In every group, there was a drop in microhardness from the baseline to demineralization. In all three test groups, the shift in microhardness values from demineralization to remineralization was shown to be statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher remineralizing capacity was found in bioactive glass and self-assembling peptide (P11-4), which can be employed therapeutically to treat early carious lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_898_24","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T02:00:34Z","timestamp":1732068034000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion"],"prefix":"10.4103","author":[{"given":"Rashmi P","family":"Yadahalli","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PMNM Dental College and Hospital, Bagalkote, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazeed Abdullah","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"General Dentist, Qassim University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, MMCDSR, Mullana, Ambala Cantt, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Najmuddin","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, KSA, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Tharwat","family":"Salama","sequence":"additional","affiliation":[{"name":"Senior Lecturer in Paediatric Dentistry, Orthodontics and Paediatric Dentistry Department, Qassim University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha Prasanna","family":"Dalai","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan (Deemed to be) University, Bubhaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry and Orthodontics, Dental College, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vardarajula Venkat","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene, College of Applied Health Sciences, Ar Rass Qassim University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"R1-20250114","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1590\/1678-775720150583","article-title":"Evaluation of the remineralization capacity of CPP-ACP containing fluoride varnish by different quantitative methods","volume":"24","author":"Savas","year":"2016","journal-title":"J Appl Oral Sci"},{"key":"R2-20250114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4034\/PBOCI.2019.191.23","article-title":"An in vitro evaluation of remineralizing capacity of self-assembling peptide (SAP) P11-4 and casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) on artificial enamel","volume":"19","author":"Babaji","year":"2019","journal-title":"Pesqui Bras Odontopediatria Cl\u00edn Integr"},{"key":"R3-20250114","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5005\/jp-journals-10005-1603","article-title":"Recent advances in dental hard tissue remineralization: A review of literature","volume":"12","author":"Arifa","year":"2019","journal-title":"Int J Clin Pediatr Dent"},{"key":"R4-20250114","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4103\/ccd.ccd_679_18","article-title":"Comparative evaluation of the remineralizing potential of commercially available agents on artificially demineralized human enamel: An in vitro study","volume":"10","author":"Joshi","year":"2019","journal-title":"Contemp Clin Dent"},{"key":"R5-20250114","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5005\/jp-journals-10024-3006","article-title":"Assessment of remineralization capacity of various remineralizing agents on artificial enamel lesions using confocal laser scanning microscope: An in vitro study","volume":"22","author":"Singh","year":"2021","journal-title":"J Contemp Dent Pract"},{"key":"R6-20250114","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0972-0707.62634","article-title":"Remineralization potential of fluoride and amorphous calcium phosphate-casein phospho peptide on enamel lesions: An in vitro comparative evaluation","volume":"13","author":"Lata","year":"2010","journal-title":"J Conserv Dent"},{"key":"R7-20250114","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0972-0707.108185","article-title":"Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study","volume":"16","author":"Patil","year":"2013","journal-title":"J Conserv Dent"},{"key":"R8-20250114","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/0972-0707.114347","article-title":"Evaluation to determine the caries remineralization potential of three dentifrices: An in vitro study","volume":"16","author":"Balakrishnan","year":"2013","journal-title":"J Conserv Dent"},{"key":"R9-20250114","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4103\/ijdr.IJDR_326_16","article-title":"In vitro evaluation of remineralization potential of novamin on artificially induced carious lesions in primary teeth using scanning electron microscope and vickers hardness","volume":"30","author":"Gangwar","year":"2019","journal-title":"Indian J Dent Res"},{"key":"R10-20250114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/pboci.2024.018","article-title":"Assessment of efficiency of bioactive glass, self-assembling peptide, and ozone remineralising agents on artificial carious lesion","volume":"24","author":"Alessa","year":"2024","journal-title":"Pesqui Bras Odontopediatria Cl\u00edn Integr"},{"key":"R11-20250114","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/ijdr.ijdr_704_22","article-title":"Evaluation of remineralising capacity of Tricalcium phosphate, Nano-hydroxyapatite (nHAp), and ozone remineralising agents on artificial carious lesion","volume":"35","author":"Shah","year":"2024","journal-title":"Indian J Dent Res"},{"issue":"Suppl 1","key":"R12-20250114","doi-asserted-by":"crossref","first-page":"S720","DOI":"10.4103\/jpbs.jpbs_963_23","article-title":"Assessment of antibacterial effectiveness of SDF and fluoride varnish agents for application in pediatric dentistry","volume":"16","author":"Alessa","year":"2024","journal-title":"J Pharm Bioallied Sci"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_898_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:59Z","timestamp":1787837459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_898_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":12,"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_898_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"2024-07-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}